Issue 10, 2014
From the journal:

Natural Product Reports

Biosynthesis of fungal indole alkaloids

Wei Xu,a   Diego J. Gaviab  and  Yi Tang*ab  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA, USA
E-mail: yitang@ucla.edu

b Department of Chemistry and Biochemistry, University of California, Los Angeles, 615 Charles E Young Dr, Los Angeles, CA, USA

Abstract

Covering: up to 2014

This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to incorporate and derivatize the indole/indoline moieties in various families of fungal indole alkaloids will be discussed, including tryptophan-containing nonribosomal peptides, polyketide-nonribosomal peptide hybrids, and alkaloids derived from other indole building blocks. This review also includes a discussion regarding the downstream modifications that generate chemical and structural diversity among indole alkaloids.

Graphical abstract: Biosynthesis of fungal indole alkaloids

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Article information

DOI
https://doi.org/10.1039/C4NP00073K
Article type
Review Article
Submitted
30 mai 2014
First published
02 sept. 2014

Nat. Prod. Rep., 2014,31, 1474-1487

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Biosynthesis of fungal indole alkaloids

W. Xu, D. J. Gavia and Y. Tang, Nat. Prod. Rep., 2014, 31, 1474 DOI: 10.1039/C4NP00073K

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