Issue 66, 2020

Copper-catalysed ortho-selective C–H bond functionalization of phenols and naphthols with α-aryl-α-diazoesters

Abstract

Herein, we reported the first copper-catalyzed highly efficient C(sp2)–H functionalization of unprotected naphthols and phenols with α-aryl-α-diazoesters. In this transformation, CuCl2 efficiently promoted the highly chemo- and site-selective C–H bond functionalization under mild conditions, furnishing diverse phenol derivatives in moderate to excellent yields from readily available starting materials.

Graphical abstract: Copper-catalysed ortho-selective C–H bond functionalization of phenols and naphthols with α-aryl-α-diazoesters

Supplementary files

Article information

Article type
Communication
Submitted
30 juin 2020
Accepted
09 juil. 2020
First published
09 juil. 2020

Chem. Commun., 2020,56, 9485-9488

Copper-catalysed ortho-selective C–H bond functionalization of phenols and naphthols with α-aryl-α-diazoesters

B. Ma, Z. Tang, J. Zhang and L. Liu, Chem. Commun., 2020, 56, 9485 DOI: 10.1039/D0CC04495D

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