Issue 64, 2016

Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

Abstract

An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin’s role in designing new cancer-specific drug delivery frameworks.

Graphical abstract: Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

Supplementary files

Article information

Article type
Communication
Submitted
20 mai 2016
Accepted
08 juil. 2016
First published
08 juil. 2016

Chem. Commun., 2016,52, 9965-9968

Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

J. H. Jang, H. Lee, A. Sharma, S. M. Lee, T. H. Lee, C. Kang and J. S. Kim, Chem. Commun., 2016, 52, 9965 DOI: 10.1039/C6CC04255D

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