A convenient method to access functionalized tetrahydropyrrolo[1,2-a]quinolinone skeletons has been achieved through a CoCl2/AgSbF6-catalyzed Povarov reaction of unactivated N-Ar N,O-acetals with styrene-type olefins.
An acid-catalyzed aminomethylative etherification of N-allenamides with N,O-acetals has been achieved under mild reaction conditions.
An efficient approach to access chiral N-α indole substituted pyrrolidine and piperidine skeletons has been developed through a AgSbF6-catalyzed N-α aza-Friedel–Crafts alkylation of N,O-acetals 6a, 6b, 9, and 11a–11d with indoles.
A phosphoric acid-catalyzed regio- and enantioselective N2-propargylation of pyridazinones and 2-pyridones has been achieved.
Access to spiro-α-iodo-γ-lactones via multidirectional consecutive double 5-exo-dig cyclization.