A convenient method to access functionalized tetrahydropyrrolo[1,2-a]quinolinone skeletons has been achieved through a CoCl2/AgSbF6-catalyzed Povarov reaction of unactivated N-Ar N,O-acetals with styrene-type olefins.
A catalyzed process for the synthesis of the 4,6-substituted 3,4-dihydro-1,3-oxazin-2-one skeleton has been developed through cycloaddition of in situ generated acyliminium intermediates with alkynes.
A practical approach to α-aminophosphonates has been developed through an In(OTf)3-catalyzed N-α phosphonylation of N,O-acetals with triethyl phosphite 7.
An efficient approach to access functionalized indole derivatives has been developed through Cu(OTf)2-catalyzed C3 aza-Friedel–Crafts alkylation of substituted indoles 5a–5m, N-methyl-pyrrole with linear N,O-acetals 4a–4l.
An acid-catalyzed aminomethylative etherification of N-allenamides with N,O-acetals has been achieved under mild reaction conditions.