Synthesis of tetrahydropyrrolo[1,2-a]quinolinone analogues via CoCl2/AgSbF6-catalyzed cyclization of unactivated N,O-acetals with olefins

Abstract

A convenient method to access functionalized tetrahydropyrrolo[1,2-a]quinolinone skeletons has been achieved through a CoCl₂/AgSbF₆-catalyzed Povarov reaction of unactivated N-Ar N,O-acetals with styrene-type olefins. As a result, a series of 5-substituted tetrahydropyrrolo[1,2-a]quinolinone derivatives were conveniently obtained in moderate to good yields.