Issue 13, 2015
From the journal:

Chemical Society Reviews

Biosensing by luminogens with aggregation-induced emission characteristics†

Ryan T. K. Kwok,‡ab   Chris W. T. Leung,‡ab   Jacky W. Y. Lamab  and  Ben Zhong Tang*abc  

* Corresponding authors

a HKUST-Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-Tech Park, Nanshan, Shenzhen 518057, China

b Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials and Division of Biomedical Engineering, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

c SCUT-HKUST Joint Research Laboratory, Guangdong Innovative Research Team and State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, China

Abstract

Fluorescent biosensors are powerful analytical tools for studying biological events in living systems. Luminescent materials with aggregation-induced emission (AIE) attributes have attracted much research interest and have been identified as a novel class of luminogens to develop fluorescent turn-on biosensors with superior sensitivity. In this Tutorial Review, we present an overview of the AIE phenomenon and its mechanism. We summarize the structural design and working principle of AIE biosensors developed recently. Typical examples of AIE biosensors are presented.

Graphical abstract: Biosensing by luminogens with aggregation-induced emission characteristics

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Article information

DOI
https://doi.org/10.1039/C4CS00325J
Article type
Tutorial Review
Submitted
29 sep. 2014
First published
06 nov. 2014

Chem. Soc. Rev., 2015,44, 4228-4238

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Biosensing by luminogens with aggregation-induced emission characteristics

R. T. K. Kwok, C. W. T. Leung, J. W. Y. Lam and B. Z. Tang, Chem. Soc. Rev., 2015, 44, 4228 DOI: 10.1039/C4CS00325J

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