Issue 13, 2015

Probing disease-related proteins with fluorogenic composite materials


Construction of composite materials based on the self-assembly of fluorescently labeled biomolecules with a variety of micro- or nano-quenching materials (by the Förster Resonance Energy Transfer mechanism) for the fluorogenic recognition of disease-related proteins has become a dynamic research topic in the field of fluorescence recognition. Here we summarize the recent progress on the composition of fluorescence dye-labeled biomolecules including sugars, peptides and nucleotides with organic (graphene and carbon nanotubes) and inorganic (gold nanoparticles) materials. Their application in the fluorescence detection of proteins and enzymes on both the molecular and cellular levels is discussed. Perspectives are proposed with respect to the future directions of employing these composite materials in the recognition of pathological proteins.

Graphical abstract: Probing disease-related proteins with fluorogenic composite materials

Article information

Article type
Tutorial Review
23 Jul 2014
First published
04 Dec 2014
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2015,44, 4239-4248

Author version available

Probing disease-related proteins with fluorogenic composite materials

X. He, Y. Zang, T. D. James, J. Li and G. Chen, Chem. Soc. Rev., 2015, 44, 4239 DOI: 10.1039/C4CS00252K

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