Issue 16, 2022

Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis

Abstract

Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered media are described, representative of the enhanced levels of conversion made possible by the presence of a nonionic surfactant in the water, thereby enabling 1-pot chemoenzymatic catalysis. Several applications are described highlighting these modified conditions that involve both biocatalysis and chemocatalysis that are environmentally responsible, indicative of the possibilities using chemistry in water. Also included herein is technology for converting a racemic benzylic alcohol to a nonracemic primary amine, and an especially efficient synthesis of the pharmaceutical (S)-rivastigmine.

Graphical abstract: Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis

Supplementary files

Article information

Article type
Paper
Submitted
27 may. 2022
Accepted
14 jul. 2022
First published
20 jul. 2022

Green Chem., 2022,24, 6172-6178

Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis

J. Dussart-Gautheret, J. Yu, K. Ganesh, G. Rajendra, F. Gallou and B. H. Lipshutz, Green Chem., 2022, 24, 6172 DOI: 10.1039/D2GC02002E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements