Issue 76, 2019

Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Abstract

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

Graphical abstract: Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Supplementary files

Article information

Article type
Communication
Submitted
25 jul. 2019
Accepted
19 ago. 2019
First published
03 sep. 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 11358-11361

Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

A. Jiang, G. Chen, J. Xu, Y. Liu, G. Zhao, Z. Liu, T. Chen, Y. Li and T. D. James, Chem. Commun., 2019, 55, 11358 DOI: 10.1039/C9CC05759E

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