Issue 2, 2016

A structural model for multimodular NRPS assembly lines

Abstract

This viewpoint article focuses on the structures of the dissected catalytic domains of non-ribosomal peptide synthetases (NRPSs) associated with substrate selection and activation (A domain), substrate shuttling among the active sites (PCP domain), peptide bond formation (C domain) and product release (TE domain). Structural details of these essential components of the NRPS machinery, integrated in a didomain (PCP-C) and an elongation module (C-A-PCP), were used to generate a model for a multimodular NRPS assembly line.

Graphical abstract: A structural model for multimodular NRPS assembly lines

Article information

Article type
Viewpoint
Submitted
28 jul. 2015
First published
02 oct. 2015

Nat. Prod. Rep., 2016,33, 136-140

Author version available

A structural model for multimodular NRPS assembly lines

M. A. Marahiel, Nat. Prod. Rep., 2016, 33, 136 DOI: 10.1039/C5NP00082C

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