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Issue 2, 2016
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Stereocontrol within polyketide assembly lines

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Abstract

Covering: 2006 to 2015

Most of the stereocenters of polyketide natural products are established during assembly line biosynthesis. The body of knowledge for how stereocenters are set is now large enough to begin constructing physical models of key reactions. Interactions between stereocenter-forming enzymes and polyketide intermediates are examined here at atomic resolution, drawing from the most current structural and functional information of ketosynthases (KSs), ketoreductases (KRs), dehydratases (DHs), enoylreductases (ERs), and related enzymes. While many details remain to be experimentally determined, our understanding of the chemical and physical mechanisms utilized by the chirality-molding enzymes of modular PKSs is rapidly advancing.

Graphical abstract: Stereocontrol within polyketide assembly lines

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Publication details

The article was received on 11 Aug 2015 and first published on 19 Nov 2015


Article type: Highlight
DOI: 10.1039/C5NP00092K
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Citation: Nat. Prod. Rep., 2016,33, 141-149

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    Stereocontrol within polyketide assembly lines

    A. T. Keatinge-Clay, Nat. Prod. Rep., 2016, 33, 141
    DOI: 10.1039/C5NP00092K

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