RSC Advances
Medical diagnostics articles published in the last
6 months
Carboxyl-functionalized two-dimensional MXene–Au nanocomposites were prepared as SERS substrates for the detection of melamine in dairy products
In the present study, we address the limitations of conventional surface-enhanced Raman scattering (SERS) techniques for sensitive and stable detection of melamine in food products, especially dairy.
RSC Adv., 2024,14, 14041-14050
https://doi.org/10.1039/D4RA02249A
Detection of intracellular microRNA-21 for cancer diagnosis by a nanosystem containing a ZnO@polydopamine and DNAzyme probe
The novel nanosystem composed of ZnO@polydopamine nanomaterial and deoxyribozyme probe can be applied for ratiometric fluorescence assay for microRNA-21, which is helpful for cancer diagnosis and prognosis.
RSC Adv., 2024,14, 13351-13360
https://doi.org/10.1039/D4RA00636D
Automatic microdispenser-integrated multiplex enzyme-linked immunosorbent assay device with autonomously driven centrifugal microfluidic system
A design theory for an autonomously driven dispenser was established. The multiplexed ELISA device was integrated with the dispenser and CLOCK circuits, and successfully prepared a calibration curve of mouse IgG by rotating at a constant speed.
RSC Adv., 2024,14, 13827-13836
https://doi.org/10.1039/D4RA02656J
Selection, characterization, and biosensing applications of DNA aptamers targeting cyanotoxin BMAA
Scientists have established a connection between environmental exposure to toxins like β-N-methylamino-L-alanine (BMAA) and a heightened risk of neurodegenerative disorders.
RSC Adv., 2024,14, 13787-13800
https://doi.org/10.1039/D4RA02384F
Rapid and quantitative detection of DNA hybridization using a simplified Fabry–Perot interferometric biosensor
The simple-structured Fabry–Perot interferometric biosensor is capable of rapid and quantitative detection of DNA hybridization.
RSC Adv., 2024,14, 13367-13373
https://doi.org/10.1039/D4RA01390E
A multi-channel microfluidic platform based on human flavin-containing monooxygenase 3 for personalised medicine
A microfluidic platform with immobilized human flavin-containing monooxygenase for high-throughput screening of drugs with relevance to personalised medicine.
RSC Adv., 2024,14, 13209-13217
https://doi.org/10.1039/D4RA01516A
Quantitative analysis of the illegal addition of Atenolol in Panax notoginseng based on NIR–MIR spectral data fusion and calibration transfer
To address the issue of the common illegal addition of Atenolol in Panax notoginseng, we propose an approach that realizes multivariate calibration transfer between different particle sizes based on spectral data fusion.
RSC Adv., 2024,14, 12428-12437
https://doi.org/10.1039/D3RA08183D
Label-free detection of Aβ-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis
This study introduces a biosensor based on liquid crystals (LC) designed to detect the Aβ-42 biomarker, commonly associated with Alzheimer's disease.
RSC Adv., 2024,14, 12107-12118
https://doi.org/10.1039/D4RA00615A
Detection of SARS-CoV-2 N protein using AgNPs-modified aligned silicon nanowires BioSERS chip
A sensitive and selective bioSERS chip was developed for the detection of nucleocapsid protein from SARS-CoV-2 virus, applied to sense the N protein in human blood serum.
RSC Adv., 2024,14, 12071-12080
https://doi.org/10.1039/D4RA00267A
Skin emitted volatiles analysis for noninvasive diagnosis: the current advances in sample preparation techniques for biomedical application
Analytical technique for monitoring skin-emitted metabolites to diagnose diseases.
RSC Adv., 2024,14, 12009-12020
https://doi.org/10.1039/D4RA01579G
Detection and photothermal inactivation of Gram-positive and Gram-negative bloodstream bacteria using photonic crystal biosensor and plasmonic core–shell
This study introduces a tailored theoretical framework for a one-dimensional photonic crystal biosensor composed of (ZrO2/GaN)N/defect layer/(ZrO2/GaN)N, designed to detect Gram-positive and Gram-negative bloodstream bacteria employing the transfer matrix method.
RSC Adv., 2024,14, 11594-11603
https://doi.org/10.1039/D4RA01802H
Greening the pathways: a comprehensive review of sustainable synthesis strategies for silica nanoparticles and their diverse applications
The graphical abstract describes several synthetic routes of SiNPs and wide range of applications of this nanoparticle.
RSC Adv., 2024,14, 11197-11216
https://doi.org/10.1039/D4RA01047G
A novel fluorescence probe for simultaneous detection of mitochondrial viscosity in hepatic ischemia reperfusion injury models
A versatile probe with mitochondria targeting, PN, for detection of viscosity alteration in HIRI mouse model was fabricated. PN had high sensitivity and selectivity, and with a large Stokes shift (∼190 nm) for viscosity. PN is expected to be used for early diagnosis and treatment assessment of HIRI disease, and also provides diagnostic basis for other related diseases.
RSC Adv., 2024,14, 11151-11156
https://doi.org/10.1039/D4RA00959B
Recent advances in photothermal nanomaterials-mediated detection of circulating tumor cells
This review summarizes the application of various photothermal materials in the detection of circulating tumor cells (CTCs), and describes the significance of CTCs detection for early tumor diagnosis and tumor prognosis.
RSC Adv., 2024,14, 10672-10686
https://doi.org/10.1039/D4RA00548A
LC-MS/DIA-based strategy for comprehensive flavonoid profiling: an Ocotea spp. applicability case
A user-friendly LC-MS data-independent acquisition-based strategy using open software for access to the flavonoid content of complex mixtures.
RSC Adv., 2024,14, 10481-10498
https://doi.org/10.1039/D4RA01384K
A new green fluorimetric micelle complexation approach for reduction of the consumed solvent and quantification of avapritinib in biological fluids
A novel green fluorimetric approach for quantifying avapritinib in biological fluids (pharmacokinetic study).
RSC Adv., 2024,14, 10445-10451
https://doi.org/10.1039/D4RA01198H
Electrochemical sensing of B-complex vitamins: current challenges and future prospects with microfluidic integration
Vitamins are crucial micronutrients found in limited quantities in food, living organisms, and soil.
RSC Adv., 2024,14, 10331-10347
https://doi.org/10.1039/D4RA00555D
In situ imaging of mRNA transcripts based on split-aptamer and split protein in living cells
Messenger RNA (mRNA) is an essential component of cell development and growth.
RSC Adv., 2024,14, 10146-10151
https://doi.org/10.1039/D3RA08475B
Recent advances in the fluorimetric and colorimetric detection of cobalt ions
Cobalt is an essential metal to maintain several functions in the human body and is present in functional materials for numerous applications.
RSC Adv., 2024,14, 9819-9847
https://doi.org/10.1039/D4RA00445K
Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors
Carcinoembryonic antigens (CEAs) are prominent cancer biomarkers that enable the early detection of numerous cancers.
RSC Adv., 2024,14, 9571-9586
https://doi.org/10.1039/D3RA07059J
Switch-on near infrared emission in albumin behind dark fabric: toward application in forensic latent bloodstain detection
Near infrared switch-on emission of SO3C7 in albumin allows imaging behind dark fabric which can inhibit latent blood stain detection.
RSC Adv., 2024,14, 9254-9261
https://doi.org/10.1039/D4RA00756E
Ultrasensitive colorimetric detection of creatinine via its dual binding affinity for silver nanoparticles and silver ions
Creatinine detection via dual binding affinity for silver nanoparticles and silver ions.
RSC Adv., 2024,14, 9114-9121
https://doi.org/10.1039/D3RA08736K
Real-time fluorescent monitoring of phase I xenobiotic-metabolizing enzymes
Applications of chemosensors of phase I metabolizing enzymes.
RSC Adv., 2024,14, 8837-8870
https://doi.org/10.1039/D4RA00127C
An innovative transportable immune device for the recognition of α-synuclein using KCC-1-nPr-CS2 modified silver nano-ink: integration of pen-on-paper technology with biosensing toward early-stage diagnosis of Parkinson's disease
Parkinson's disease (PD), the second most frequent neurodegenerative illness, is a neurological ailment that produces unintentional or uncontrolled body movements, which should be diagnosed in its early stages to hinder the progression.
RSC Adv., 2024,14, 8810-8818
https://doi.org/10.1039/D3RA07058A
A prototype of ultrasensitive time-resolved fluoroimmunoassay for the quantitation of lead in plasma using a fluorescence-enhanced europium chelate label for the detection system
This study describes the development and validation of a prototype time-resolved fluoroimmunoassay (TRFIA) for the quantification of lead in plasma. The assay is valuable for controlling the exposure of humans to potential lead toxicities.
RSC Adv., 2024,14, 8671-8683
https://doi.org/10.1039/D3RA07673C
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