A superior method for antitumor therapy and application: dual-ligand nanomedicines
Schematic illustration of dual-ligand nanomedicines navigating the tumor microenvironment and selectively targeting tumor cells through enhanced binding affinity and cellular uptake.
Structural aspects of dimeric prodrug-based carrier-free nanomedicines for tumor chemotherapy
The effect of the flexible linker length in the dimeric prodrugs was explained by their aggregation structures and revealed through molecular dynamics simulation.
Membrane Fusogenic Liposomes Facilitate the Production of Immunostimulatory Extracellular Vesicles for Enhanced Cancer Therapy
A biomimetic therapeutic nanovaccine based on dendrimer–drug conjugates coated with metal–phenolic networks for combination therapy of nasopharyngeal carcinoma: an in vitro investigation
A biomimetic nanovaccine based on dendrimer–drug conjugates coated with metal–phenolic networks is constructed for combination therapy, eliciting immune responses for maturation of dendritic cells and M1 polarization of tumor-associated macrophages.
Paper
Self-targeted nanosystem for enhanced chemodynamic cancer therapy
A schematic illustration of ZnNP enhanced CDT for HGSOC. ZnNP promotes the tumor-specific generation of bioactive H2O2, which subsequently triggers ROS-dependent apoptotic cell death.
Novel doxycycline gold nanoparticles via green synthesis using PEO-PPO block copolymers for enhanced radiosensitization of melanoma
Green-synthesized gold nanoparticles using PEO-PPO copolymers serve as stable, biocompatible nanoplatforms for doxycycline, enhancing melanoma radiosensitivity and supporting sustainable cancer therapy development.
Traditional Chinese medicine (TCM) enhances the therapeutic efficiency of a gemcitabine-loaded injectable hydrogel on postoperative breast cancer through modulating the microenvironment
GEM-hydrogel was prepared for local treatment of postoperative breast cancer. Meanwhile, SBP was given to normalize the blood vessels for enhancing drug perfusion by promoting PDGFB expression, pericytes recruiting and alleviating hypoxia.
A Nd–Yb ratiometric luminescent nanothermometer for assessing thermal resistance discrepancies between A549 and BEAS-2B cells to achieve selective hyperthermia
A Nd–Yb codoped luminescent nanothermometer is used for assessing thermal resistance discrepancies between lung cancer cells (A549) and normal lung cells (BEAS-2B). A549 with lower heat resistance could be selectively killed by optimal hyperthermia.
About this collection
Given the widespread occurrence of cancer across the world, many researchers are focusing attention on ways in which we can prevent, treat and control cancer. Developments in using more targeted approaches such as gene therapy and nanomedicines, as well as general approaches such as chemotherapy, photothermal therapy and immunotherapy are all being reported to improve therapeutic response to cancer and to cause minimal side effects to unaffected regions of the body. The use of materials in developing and improving treatments is integral and as such this collection aims to collate some of the latest research developments using materials in cancer therapeutics. The broad scope of this collection across Journal of Materials Chemistry B and Biomaterials Science hopes to capture a range of timely research from the fundamentals of materials chemistry to the applications of biomaterials in diagnosing, controlling and treating cancer.
This collection is guest edited by Prof. Jong Seung Kim (Korea University), Prof. Tao Sun (Fudan University), Prof. Qingbing Wang (Ruijin Hospital, Shanghai Jiaotong University School of Medicine) and Prof. Jennifer Cha (University of Colorado, Boulder).