Themed collection JMC B Top Picks collection: Recent advances in drug delivery

20 items
Feature Article

Electrospun membranes: control of the structure and structure related applications in tissue regeneration and drug delivery

Multilevel structures of electrospun membranes can be controlled and the designed structures can strongly affect cell behavior and drug delivery.

Graphical abstract: Electrospun membranes: control of the structure and structure related applications in tissue regeneration and drug delivery
Feature Article

Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges

Gold nanoparticles and their conjugates as drug delivery vehicles for selective targeting of cancer cells.

Graphical abstract: Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges
Feature Article

Dendrimers for drug delivery

Schematized types of interactions of dendrimers with drugs or biologically active substances.

Graphical abstract: Dendrimers for drug delivery
Feature Article

Chemical modification of inorganic nanostructures for targeted and controlled drug delivery in cancer treatment

This review summarized the most advanced designs of stimuli-responsive drug delivery systems based on inorganic nanoparticles.

Graphical abstract: Chemical modification of inorganic nanostructures for targeted and controlled drug delivery in cancer treatment
Review Article

Stimuli responsive drug delivery application of polymer and silica in biomedicine

In the last decade, using polymer and mesoporous silica materials as efficient drug delivery carriers has attracted great attention.

Graphical abstract: Stimuli responsive drug delivery application of polymer and silica in biomedicine
Review Article

Design of hybrid nanovehicles for remotely triggered drug release: an overview

This review addresses the advantages of remote triggers, e.g. ultrasounds, near infrared light and alternating magnetic fields, the fabrication of the hybrid nanovehicles, the release mechanisms and the next challenges.

Graphical abstract: Design of hybrid nanovehicles for remotely triggered drug release: an overview
Communication

Porphyrin-functionalized mesoporous organosilica nanoparticles for two-photon imaging of cancer cells and drug delivery

The synthesis of porphyrin-functionalized ethylene-based mesoporous organosilica nanoparticles was performed.

Graphical abstract: Porphyrin-functionalized mesoporous organosilica nanoparticles for two-photon imaging of cancer cells and drug delivery
Communication

Graphene quantum dot-capped mesoporous silica nanoparticles through an acid-cleavable acetal bond for intracellular drug delivery and imaging

Herein, the luminescent GQD gated nanocarriers not only responded to the pH signals in cancer cells, but also tracked the delivery of anticancer drugs.

Graphical abstract: Graphene quantum dot-capped mesoporous silica nanoparticles through an acid-cleavable acetal bond for intracellular drug delivery and imaging
Paper

Target delivery of β-cyclodextrin/paclitaxel complexed fluorescent carbon nanoparticles: externally NIR light and internally pH sensitive-mediated release of paclitaxel with bio-imaging

The carbonized fluorescence hyaluronic acid (HA-FCN) for triggered target bioimaging ability have conjugated with β-cyclodextrin (CD) to release PTX by intracellular pH as well as remote photothermal NIR light control.

Graphical abstract: Target delivery of β-cyclodextrin/paclitaxel complexed fluorescent carbon nanoparticles: externally NIR light and internally pH sensitive-mediated release of paclitaxel with bio-imaging
Paper

Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery

Doxorubicin is effectively loaded into disulfide-crosslinked poly(N-isopropylacrylamide-co-acrylic acid) nanogels, which can be triggerably released in a heating or reducing acidic tumor microenvironment.

Graphical abstract: Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery
Paper

Cationic liposomes as efficient nanocarriers for the drug delivery of an anticancer cholesterol-based ruthenium complex

Cationic nanovectors loaded with Ru-based nucleolipids exert a high growth-inhibitory activity against human cancer cells (MCF-7 (A), WiDr (B), and HeLa (C)).

Graphical abstract: Cationic liposomes as efficient nanocarriers for the drug delivery of an anticancer cholesterol-based ruthenium complex
Paper

Biodegradable glycopolymer-b-poly(ε-caprolactone) block copolymer micelles: versatile construction, tailored lactose functionality, and hepatoma-targeted drug delivery

An illustration of versatile construction of biodegradable glycopolymer-PCL micelles with tailored LBA-functionality for hepatoma-targeted drug delivery.

Graphical abstract: Biodegradable glycopolymer-b-poly(ε-caprolactone) block copolymer micelles: versatile construction, tailored lactose functionality, and hepatoma-targeted drug delivery
Paper

Porous hollow microspheres of amorphous calcium phosphate: soybean lecithin templated microwave-assisted hydrothermal synthesis and application in drug delivery

Microwave-assisted hydrothermal synthesis of porous hollow microspheres of amorphous calcium phosphate using adenosine triphosphate, CaCl2 and soybean lecithin is reported.

Graphical abstract: Porous hollow microspheres of amorphous calcium phosphate: soybean lecithin templated microwave-assisted hydrothermal synthesis and application in drug delivery
Paper

Tunable stellate mesoporous silica nanoparticles for intracellular drug delivery

Tunable stellate mesoporous silica nanoparticles are functionalized with low molecular poly(ethylene imine) for efficient label-free intracellular drug delivery.

Graphical abstract: Tunable stellate mesoporous silica nanoparticles for intracellular drug delivery
Paper

Application of paramagnetic graphene quantum dots as a platform for simultaneous dual-modality bioimaging and tumor-targeted drug delivery

This paper reports the development of a multifunctional nanocarrier platform consisting of paramagnetic graphene quantum dots, folate, and doxorubicin for simultaneous fluorescence and MR imaging, and cancer treatment.

Graphical abstract: Application of paramagnetic graphene quantum dots as a platform for simultaneous dual-modality bioimaging and tumor-targeted drug delivery
Paper

A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles

A smart drug delivery system, DOX@MSN-S-S-RGD, was constructed by anchoring the RGD containing peptides onto the surface of MSNs using disulfide bonds for enhanced tumor cellular uptake and subsequent efficient cell killing.

Graphical abstract: A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles
Paper

Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention

Antimicrobial activity of antibiotic-loaded silica nanoparticle–collagen composite hydrogels.

Graphical abstract: Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention
Paper

Supramolecular nanoparticle carriers self-assembled from cyclodextrin- and adamantane-functionalized polyacrylates for tumor-targeted drug delivery

A self-assembly approach is developed for the fabrication of doxorubicin-loaded supramolecular nanoparticles for targeted drug delivery for in vitro and in vivo cancer treatment.

Graphical abstract: Supramolecular nanoparticle carriers self-assembled from cyclodextrin- and adamantane-functionalized polyacrylates for tumor-targeted drug delivery
Paper

Graphitic-phase C3N4 nanosheets as efficient photosensitizers and pH-responsive drug nanocarriers for cancer imaging and therapy

We demonstrate that g-C3N4 nanosheets with excellent biocompatibility can be employed as photosensitizers and drug nanocarriers for cancer imaging and therapy.

Graphical abstract: Graphitic-phase C3N4 nanosheets as efficient photosensitizers and pH-responsive drug nanocarriers for cancer imaging and therapy
Paper

Screening of bio-compatible metal–organic frameworks as potential drug carriers using Monte Carlo simulations

GCMC simulation is the workhorse for simulating adsorption phenomena, explaining and predicting new experimental results for drug delivery applications.

Graphical abstract: Screening of bio-compatible metal–organic frameworks as potential drug carriers using Monte Carlo simulations
20 items

About this collection

This second in a series of JMC B Top Picks web collections highlights some of the best research in drug delivery.

Journal of Material Chemistry B’s Associate Editor Tracy Cui (University of Pittsburgh, USA) highlights some of the journal’s best papers in drug delivery. The field of drug delivery has reached an exciting era where novel materials and nanotechnologies are used to design delivery systems that are more sophisticated and intelligent than ever. 

Presented to you is a collection of articles describing the latest advances in drug delivery. The novel materials highlighted here include organic materials such as dendrimers, polymers and liposomes, inorganics including various nanoparticles of silica, gold and carbon, and organic-inorganic hybrids such as metal organic frameworks. Each delivery system reported here is designed to present the ability to target, to release drugs in response to local biochemical cues (pH, redox), or remote triggers (magnetic, electrical, optical and thermal), and to provide additional diagnostic functionality. Utilizing novel chemistry and novel material properties, these advanced drug delivery systems are poised to provide more effective therapies to various devastating diseases.

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