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Themed collection 2016 Organic Chemistry Frontiers Review-type Articles

11 items
Open Access Highlight

New strategies and applications using electrophilic cyanide-transfer reagents under transition metal-free conditions

The use of electrophilic cyanide-transfer reagents has become a versatile strategy to access important structural motives in a complementary way compared to other methods.

Graphical abstract: New strategies and applications using electrophilic cyanide-transfer reagents under transition metal-free conditions
Highlight

Ruthenium-catalysed hydrosilylation of carbon–carbon multiple bonds

Recent advances in ruthenium-catalysed hydrosilylation of C–C multiple bonds and its application to organic synthesis are highlighted.

Graphical abstract: Ruthenium-catalysed hydrosilylation of carbon–carbon multiple bonds
Highlight

C(sp3)–H bond functionalization by sequential hydride transfer/cyclization: electronic effect and steric effect controlled regioselectivity

The electronic effect and steric effect have a dramatic impact on the fascinating cascade [1,n]-hydride transfer/cyclization. The regioselectivity of two potential hydrogen donors could be perfectly tuned to construct different skeletons.

Graphical abstract: C(sp3)–H bond functionalization by sequential hydride transfer/cyclization: electronic effect and steric effect controlled regioselectivity
Highlight

Photoredox sheds new light on nickel catalysis: from carbon–carbon to carbon–heteroatom bond formation

Recent emergence of photoredox/nickel dual catalysis to generate carbon–carbon and carbon–heteroatom bonds is highlighted.

Graphical abstract: Photoredox sheds new light on nickel catalysis: from carbon–carbon to carbon–heteroatom bond formation
Highlight

A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations

Fluorinated solvents like 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and trifluoroethanol (TFE) have recently emerged as a remarkable synthetic hint allowing challenging C–H activation reactions.

Graphical abstract: A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations
Review Article

Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations

This review covers new developments in the transition metal-catalyzed allylic alkylations of non-stabilized enolates, preferentially generated from ketone, esters or amides.

Graphical abstract: Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations
Review Article

Beyond Fischer and Schrock carbenes: non-heteroatom-stabilized group 6 metal carbene complexes – a general overview

Non-heteroatom-stabilized group 6 metal carbene complexes: versatile reagents or intermediates in stoichiometric or catalytic reactions in organic synthesis.

Graphical abstract: Beyond Fischer and Schrock carbenes: non-heteroatom-stabilized group 6 metal carbene complexes – a general overview
Review Article

Recent progress in rhodium-catalyzed hydroaminomethylation

This review covers the recent studies featuring the development of catalysts for alkene hydroaminomethylation.

Graphical abstract: Recent progress in rhodium-catalyzed hydroaminomethylation
Review Article

Learning lessons from directed evolution of stereoselective enzymes

With the advent of directed evolution of stereoselective enzymes almost 20 years ago and the rapid development of this exciting area of research, the traditional limitations of biocatalysts in organic chemistry have been eliminated.

Graphical abstract: Learning lessons from directed evolution of stereoselective enzymes
Review Article

Synthesis and reactivity of alkoxy-activated cyclobutane-1,1-dicarboxylates

Donor–acceptor (DA) cyclopropanes are extensively studied and well established as building blocks for the synthesis of highly substituted carbo- and heterocyclic compounds. Despite of similar ring strain, the homologous DA cyclobutanes were long ignored. This personal account details our group's research towards the application of DA cyclobutanes in cycloaddition chemistry.

Graphical abstract: Synthesis and reactivity of alkoxy-activated cyclobutane-1,1-dicarboxylates
Review Article

Chirality transfer in metal-catalysed intermolecular addition reactions involving allenes

This review covers chirality transfer in metal-catalysed intermolecular addition reactions involving allenes, including axial-to-central chirality transfer, asymmetric catalysis and racemization.

Graphical abstract: Chirality transfer in metal-catalysed intermolecular addition reactions involving allenes
11 items

About this collection

Review-type articles published by Organic Chemistry Frontiers in 2016 are collated as below for the benefit of readers.

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