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Themed collection Commemorative issue in honour of Jan van der Leun

14 items
Editorial

Commemorative issue in honour of Jan van der Leun, 14 June 1928–6 July 2016

Welcome to this Photochemical & Photobiological Sciences special issue dedicated to Jan van der Leun.

Graphical abstract: Commemorative issue in honour of Jan van der Leun, 14 June 1928–6 July 2016
Perspective

Phototherapy of cutaneous T-cell lymphomas

Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas arising in the skin. Phototherapy with ultraviolet radiation, introduced in 1976, is still a mainstay of treatment. Depending on CTCL variant and stage psoralen and ultraviolet A, narrow-band ultraviolet B, or photopheresis are used and can provide effective palliation for many patients.

Graphical abstract: Phototherapy of cutaneous T-cell lymphomas
Perspective

Drug and chemical induced photosensitivity from a clinical perspective

Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved.

Graphical abstract: Drug and chemical induced photosensitivity from a clinical perspective
Perspective

Melanoma – role of the environment and genetics

This paper illustrates the independent and interactive role of genetic and environmental factors in the etiology of melanoma.

Graphical abstract: Melanoma – role of the environment and genetics
Perspective

Solar UV damage to cellular DNA: from mechanisms to biological effects

Solar ultraviolet (UV) radiation generates bulky photodimers at di-pyrimidine sites that pose stress to cells and organisms by hindering DNA replication and transcription.

Graphical abstract: Solar UV damage to cellular DNA: from mechanisms to biological effects
Perspective

Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation

Based on the polη-dependent TLS across deaminated CPDs, the wavelength dependence of UVR mutations can be explained by different photochemistries of CPD formation, the singlet/triplet and collective excitations that cause UV-signature and UVA-signature mutations, respectively.

Graphical abstract: Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation
Perspective

Formation of UV-induced DNA damage contributing to skin cancer development

UV-induced DNA damage plays a key role in the initiation phase of skin cancer. Their yield and chemical structure strongly depend on the wavelength.

Graphical abstract: Formation of UV-induced DNA damage contributing to skin cancer development
Perspective

Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis

Major steps in the pathway leading to the increased risk of skin cancer by the immunosuppression induced by UVR exposure.

Graphical abstract: Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis
Paper

Low wintertime pre-diagnostic vitamin D status is associated with an increased risk of internal malignancies in kidney transplant recipients

Kidney transplant recipients with the lowest wintertime vitamin D levels appear to run the highest risk of internal malignancies. The effect was strongest in women.

Graphical abstract: Low wintertime pre-diagnostic vitamin D status is associated with an increased risk of internal malignancies in kidney transplant recipients
Paper

Climate change and its relationship with non-melanoma skin cancers

The increase in ambient temperature due to climate change is expected to affect the carcinogenicity of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).

Graphical abstract: Climate change and its relationship with non-melanoma skin cancers
Paper

Solar UV radiation and microbial life in the atmosphere

Many microorganisms are alive while suspended in the atmosphere, but are exposed to solar ultraviolet (UV) radiation from all directions. Geographic and seasonal patterns of DNA-damaging UV doses can be estimated from observations as well as modeling.

Graphical abstract: Solar UV radiation and microbial life in the atmosphere
Open Access Paper

Are current guidelines for sun protection optimal for health? Exploring the evidence

At UVI < 3, sun protection is not recommended, but UVA irradiance may be high; even short exposures may incur health risks. Duration of exposure must be considered with UVI for risks and benefits of sun exposure.

Graphical abstract: Are current guidelines for sun protection optimal for health? Exploring the evidence
Paper

Mechanisms of and variables affecting UVR photoadaptation in human skin

Humans have been exposed to solar UV radiation since their appearance on Earth and evolution has enabled most individuals to adapt to this exposure, to some degree.

Graphical abstract: Mechanisms of and variables affecting UVR photoadaptation in human skin
Paper

Ultraviolet erythema: dose response and mediator diffusion

The earliest contribution made by Jan van der Leun to the field of photobiology was studying the mechanism of UV-induced erythema in human skin – a subject he chose for his PhD in the 1960s.

Graphical abstract: Ultraviolet erythema: dose response and mediator diffusion
14 items

About this collection

This commemorative issue is in honour of the memory and achievements of Jan van der Leun, as an eminent biophysicist and warm-hearted colleague and friend.

Janet F. Bornman and Frank R. de Gruijl (Guest Editors)

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