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Themed collection Biosynthesis

26 items
Review Article

Biosynthesis of bioactive natural products from Basidiomycota

The club fungi, Basidioycota, produce a wide range of bioactive compounds. Here, we describe recent studies on the biosynthetic pathways and enzymes of bioactive natural products from these fungi.

Graphical abstract: Biosynthesis of bioactive natural products from Basidiomycota
From the themed collection: Biosynthesis
Review Article

The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

Tailoring enzymes decorate diketopiperazines to yield unique structures and biological functions.

Graphical abstract: The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases
From the themed collection: Chemical biology in OBC
Communication

Chorismatases – the family is growing

A newly discovered subfamily of chorismatases catalyses the same reaction as chorismate lyases (cleavage of chorismate to 4-hydroxybenzoate), but does not suffer from product inhibition.

Graphical abstract: Chorismatases – the family is growing
From the themed collection: Biosynthesis
Communication

Seven-enzyme in vitro cascade to (3R)-3-hydroxybutyryl-CoA

Economical and environmentally-friendly routes to convert feedstock chemicals like acetate into valuable chiral products such as (R)-3-hydroxybutyrate are in demand.

Graphical abstract: Seven-enzyme in vitro cascade to (3R)-3-hydroxybutyryl-CoA
From the themed collection: Chemical biology in OBC
Communication

SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides

A new stand-alone thioesterase, SurE, is capable of offloading two different NRPS assembly lines to generate two structurally unrelated cyclopeptides.

Graphical abstract: SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides
From the themed collection: Biosynthesis
Communication

Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers

Inactivation of the halogenase gene spmH led to discovery of four new deschloro-tryptophan dimers. SpmH was further biochemically characterized in vitro as an L-tryptophan 5-halogenase.

Graphical abstract: Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers
From the themed collection: Biosynthesis
Communication

Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider

A new method to activate fungal silent biosynthesis by using natural and synthetic plant hormones.

Graphical abstract: Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider
From the themed collection: Biosynthesis
Communication

Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway

The biosynthetic pathway of the uridine-derived nucleoside antibiotic A-94964 was proposed via in silico analysis coupled with gene deletion experiments.

Graphical abstract: Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway
From the themed collection: Chemical biology in OBC
Communication

In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid

Four enzymes direct the biosynthesis of 3-hydroxypicolinic acid, an important building block of bacterial natural products.

Graphical abstract: In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid
From the themed collection: Chemical biology in OBC
Communication

Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A

Biosynthesis of a potent MptpB inhibitor asperterpenoid A by a sesterterpene cyclase AstC and a multifunctional P450 enzyme AstB.

Graphical abstract: Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A
From the themed collection: Biosynthesis
Communication

Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

Targeted gene knockout in Coprinopsis cinerea, yeast in vivo bioconversion and in vitro assays elucidated the lagopodin biosynthetic pathway, including a complexity-generating network of oxidation steps.

Graphical abstract: Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions
From the themed collection: Chemical biology in OBC
Communication

Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

A heterologous production of asperipin-2a and determination of its absolute structure revealed a sequential oxidative cyclization catalyzed by DUF3328 oxidase.

Graphical abstract: Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase
From the themed collection: Chemical biology in OBC
Communication

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Aurantizolicin and new compound 3 with improved bioactivity were generated highly effectively by heterologous expression of an engineered YM-216391 biosynthetic gene cluster.

Graphical abstract: Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system
From the themed collection: Chemical biology in OBC
Communication

StnK2 catalysing a Pictet–Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin

StnK2 is a new Pictet–Spenglerase specifically catalyzing a (1R,3S,4S)-tetrahydro-β-carboline scaffold as the biosynthetic intermediate of the antitumor reagent streptonigrin.

Graphical abstract: StnK2 catalysing a Pictet–Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin
From the themed collection: Chemical biology in OBC
Communication

Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product.

Graphical abstract: Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans
From the themed collection: Biosynthesis
Paper

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

A methylation of the acetate starter unit is part of the polyketide biosynthesis of phthalides and phthalimidines from the marine-derived fungus Stachylidium sp. 293K04.

Graphical abstract: Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04
From the themed collection: Chemical biology in OBC
Paper

Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098

An amine hydroxylase catalyzes a latter step in the biosynthesis of the antimalarial FR900098.

Graphical abstract: Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098
From the themed collection: Chemical biology in OBC
Paper

Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs

MtdV is a chorismate lyase involved in converting chorismate to 4HB, a vital precursor of A201A; precursor-directed biosynthesis enabled production of new A201A analogs.

Graphical abstract: Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs
From the themed collection: Chemical biology in OBC
Open Access Paper

Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase

Aza-analogues of carbocations inhibit δ-cadinene synthase: 1,6-cyclisation.

Graphical abstract: Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase
From the themed collection: Chemical biology in OBC
Paper

Probing the limits of interrupted adenylation domains by engineering a trifunctional enzyme capable of adenylation, N-, and S-methylation

The adenylation (A) domains found in nonribosomal peptide synthetases (NRPSs) exhibit tremendous plasticity.

Graphical abstract: Probing the limits of interrupted adenylation domains by engineering a trifunctional enzyme capable of adenylation, N-, and S-methylation
From the themed collection: Chemical biology in OBC
Paper

Mechanistic characterization of three sesquiterpene synthases from the termite-associated fungus Termitomyces

Three terpene synthases from the termite associated fungus Termitomyces were studied by isotopic labelling experiments and site-directed mutagenesis.

Graphical abstract: Mechanistic characterization of three sesquiterpene synthases from the termite-associated fungus Termitomyces
From the themed collection: Chemical biology in OBC
Paper

Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin

An efficient method for preparing phosphonodipeptides, compounds that have potential as clinical antibiotics, is reported using enzymatic catalysis.

Graphical abstract: Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin
From the themed collection: Biosynthesis
Paper

Characterization of the N-methyltransferases involved in the biosynthesis of toxoflavin, fervenulin and reumycin from Streptomyces hiroshimensis ATCC53615

Four SAM-dependent N-methyltransferases are involved in the biosynthesis of toxoflavin, fervenulin, and reumycin from Streptomyces hiroshimensis ATCC53615.

Graphical abstract: Characterization of the N-methyltransferases involved in the biosynthesis of toxoflavin, fervenulin and reumycin from Streptomyces hiroshimensis ATCC53615
From the themed collection: Chemical biology in OBC
Paper

Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines

The new subfamily of type II PKS gene cluster is responsible for biosynthesis of structurally distinct streptoaminals (STAMs) and 5-alkyl-1,2,3,4-tetrahydroquinolines (5aTHQs).

Graphical abstract: Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines
From the themed collection: Biosynthesis
Paper

pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism

PKS dehydratases utilize a one-base mechanism.

Graphical abstract: pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway

Enzymatic activity and crystal structures of the methyltransferases involved in the biosynthesis of fungal natural products meleagrin and oxaline.

Graphical abstract: Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway
From the themed collection: Chemical biology in OBC
26 items

About this collection

This themed collection, Guest Edited by Professor Ikuro Abe, Professor Jeroen S. Dickschat, Professor Wenjun Zhang and Professor Taifo Mahmud, is a forum for the dissemination of cutting edge research on a range of topics related to the biogenesis of natural products. This will include genome mining and elucidation of biosynthetic pathway, mechanistic studies on natural product biosynthesis, studies of the genes and enzymes involved in natural product biosynthesis, enzyme engineering and biocatalysis and metabolic engineering for synthetic biology.

Articles in this themed collection will be added below as soon as possible after they are published.

Please return to this page frequently to see the collection grow.

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