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Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

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Abstract

Asperipin-2a is a ribosomally synthesized and post-translationally modified peptide isolated from Asperigillus flavus. Herein, we report the heterologous production of asperipin-2a and determination of its absolute structure. Notably, the characteristic bicyclic structure was likely constructed by a single oxidase containing the DUF3328 domain.

Graphical abstract: Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

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Publication details

The article was received on 13 Nov 2018, accepted on 28 Nov 2018 and first published on 28 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02824A
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

    Y. Ye, T. Ozaki, M. Umemura, C. Liu, A. Minami and H. Oikawa, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02824A

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