Editorial: Are natural products the solution to antimicrobial resistance?
Opportunities for natural products in 21st century antibiotic discovery
Natural product research is poised to regain prominence in delivering new drugs to solve the antibiotic crisis.
Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?
Antibiotics are a therapeutic class that, once deployed, select for resistant bacterial pathogens and so shorten their useful life cycles.
Proline-rich antimicrobial peptides targeting protein synthesis
Proline-rich antimicrobial peptides (PrAMPs) bind within the exit tunnel of the ribosome and inhibit translation elongation. Structures of ribosome-bound PrAMPs reveal the interactions with ribosomal components and could pave the way for the development of novel peptide-based antimicrobial agents.
Antibiotics and specialized metabolites from the human microbiota
Human microbiota associated with each body site produce specialized molecules to kill human pathogens. Advanced bioinformatics tools will help to discover unique microbiome chemistry.
Actinomycetes: still a source of novel antibiotics
An update on last ten years of actinomycetes antibiotic discovery, including recent key molecules in clinical development and overlooked compounds discovered using novel strategies.
Targeting a cell wall biosynthesis hot spot
History points to the bacterial cell wall biosynthetic network as a very effective target for antibiotic intervention, and numerous natural product inhibitors have been discovered.
Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
Gram-negative bacteria are a rich and underexplored source of antibiotics that are assembled via remarkably diverse biosynthetic pathways.
Recent advances and perspectives in the design and development of polymyxins
Polymyxins: background and future perspectives. Introducing metabolism and detoxification considerations into the design of new polymyxins to reduce nephrotoxicity.
Symbiosis-inspired approaches to antibiotic discovery
Advances in our understanding of symbioses, enabled by newly developed “omics” and co-culturing technologies, inspire new approaches to antibiotic discovery.
Bifunctional antimicrobial conjugates and hybrid antimicrobials
Novel antimicrobial drugs are continuously needed to counteract bacterial resistance development.
Conformational control of the bacterial Clp protease by natural product antibiotics
Natural products targeting the bacterial Clp protease unravel key interfaces for protein–protein–interaction and long-distance conformational control.
About this collection
Natural Product Reports is delighted to publish a collection of reviews focussing on novel antibiotics and antimicrobial resistance. Guest Edited by Bradley S. Moore, Guy T. Carter and Mark Brönstrup, this collection brings insight into the role of natural products play in alleviating the increasing issue of antimicrobial resistance.