Themed collection New methods for isolation and structure determination of natural products
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New methods for isolation and structure determination of natural products
The Natural Product Reports themed issue on New Methods for Isolation and Structure Determination of Natural Products is introduced by the Guest Editors, Roger Linington, Julia Kubanek and Hendrik Luesch.
Imaging mass spectrometry for natural products discovery: a review of ionization methods
This mini review discusses advantages, limitations, and examples of different mass spectrometry ionization sources applicable to natural product discovery workflows.
Innovative omics-based approaches for prioritisation and targeted isolation of natural products – new strategies for drug discovery
This review focuses on innovative omics approaches related to the prioritisation of natural extracts, to selection of efficient producing strains and to the targeted isolation of their bioactive constituents.
Vibrational optical activity for structural characterization of natural products
This review presents the recent progress towards elucidating the structures of chiral natural products and applications using vibrational optical activity (VOA) spectroscopy.
Computational prediction of chiroptical properties in structure elucidation of natural products
A tutorial review aimed to introduce natural product chemists to the predictions of natural product configurations by ECD and OR calculations.
Natural products targeting strategies involving molecular networking: different manners, one goal
This review focuses on the ever-expanding repertoire of molecular networking applications for targeting natural products.
Droplet probe: coupling chromatography to the in situ evaluation of the chemistry of nature
The chemistry of nature can be beautiful, inspiring, beneficial and poisonous, depending on perspective.
Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products
Water-soluble, volatile, minor and photosensitive natural products are yet poorly known, and this review discusses the literature reporting the isolation strategies for some of these metabolites.
Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2
This report documents the cellular, molecular, and analytical methods used to identify combination effects in complex natural product mixtures.
Applications of OR/ECD/VCD to the structure elucidation of natural products
OR, ECD and VCD are powerful methods to determine the absolute configuration of natural products either applied independently or in combination.
The role of computer-assisted structure elucidation (CASE) programs in the structure elucidation of complex natural products
Computer-assisted structure elucidation can help to determine the structures of complex natural products while minimizing the risk of structure errors.
About this collection
This themed issue is Guest Edited by Professor Julia Kubanek, Professor Roger Linington and Professor Hendrik Luesch