Themed collection New methods for isolation and structure determination of natural products

The Natural Product Reports themed issue on New Methods for Isolation and Structure Determination of Natural Products is introduced by the Guest Editors, Roger Linington, Julia Kubanek and Hendrik Luesch.

This mini review discusses advantages, limitations, and examples of different mass spectrometry ionization sources applicable to natural product discovery workflows.

This review focuses on innovative omics approaches related to the prioritisation of natural extracts, to selection of efficient producing strains and to the targeted isolation of their bioactive constituents.

This review presents the recent progress towards elucidating the structures of chiral natural products and applications using vibrational optical activity (VOA) spectroscopy.

A tutorial review aimed to introduce natural product chemists to the predictions of natural product configurations by ECD and OR calculations.

This review focuses on the ever-expanding repertoire of molecular networking applications for targeting natural products.

The chemistry of nature can be beautiful, inspiring, beneficial and poisonous, depending on perspective.

Water-soluble, volatile, minor and photosensitive natural products are yet poorly known, and this review discusses the literature reporting the isolation strategies for some of these metabolites.

This report documents the cellular, molecular, and analytical methods used to identify combination effects in complex natural product mixtures.

OR, ECD and VCD are powerful methods to determine the absolute configuration of natural products either applied independently or in combination.

Computer-assisted structure elucidation can help to determine the structures of complex natural products while minimizing the risk of structure errors.