Editing streptomycete genomes in the CRISPR/Cas9 age
This article reviews CRISPR/Cas9-based toolkits available to investigate natural product biosynthesis and regulation in streptomycete bacteria.
Harnessing diverse transcriptional regulators for natural product discovery in fungi
This review covers diverse transcriptional regulators for the activation of secondary metabolism and novel natural product discovery in fungi.
Tropolone natural products
This review on natural products containing a tropolonoid motif highlights analytical methods applied for structural identification and biosynthetic pathway analysis, the ecological context and the pharmacological potential of this compound class.
Built to bind: biosynthetic strategies for the formation of small-molecule protease inhibitors
The discovery and characterization of natural product protease inhibitors has inspired the development of numerous pharmaceutical agents.
Michael additions in polyketide biosynthesis
Enzymes that catalyze a Michael-type addition in polyketide biosynthesis are summarized and discussed.