Themed collection Emerging investigator Review series

This review covers diverse transcriptional regulators for the activation of secondary metabolism and novel natural product discovery in fungi.

This article reviews CRISPR/Cas9-based toolkits available to investigate natural product biosynthesis and regulation in streptomycete bacteria.

Ribosomally synthesised and post-translationally modified peptides (RiPPs) are highly promising candidates for drug discovery and development, but challenges remain.

The discovery and characterization of natural product protease inhibitors has inspired the development of numerous pharmaceutical agents.

This review on natural products containing a tropolonoid motif highlights analytical methods applied for structural identification and biosynthetic pathway analysis, the ecological context and the pharmacological potential of this compound class.

Enzymes that catalyze a Michael-type addition in polyketide biosynthesis are summarized and discussed.