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Themed collection Emerging investigator Review series

5 items
Open Access Highlight

Editing streptomycete genomes in the CRISPR/Cas9 age

This article reviews CRISPR/Cas9-based toolkits available to investigate natural product biosynthesis and regulation in streptomycete bacteria.

Graphical abstract: Editing streptomycete genomes in the CRISPR/Cas9 age
Highlight

Harnessing diverse transcriptional regulators for natural product discovery in fungi

This review covers diverse transcriptional regulators for the activation of secondary metabolism and novel natural product discovery in fungi.

Graphical abstract: Harnessing diverse transcriptional regulators for natural product discovery in fungi
From the themed collection: Emerging investigator Review series
Review Article

Tropolone natural products

This review on natural products containing a tropolonoid motif highlights analytical methods applied for structural identification and biosynthetic pathway analysis, the ecological context and the pharmacological potential of this compound class.

Graphical abstract: Tropolone natural products
From the themed collection: Emerging investigator Review series
Review Article

Built to bind: biosynthetic strategies for the formation of small-molecule protease inhibitors

The discovery and characterization of natural product protease inhibitors has inspired the development of numerous pharmaceutical agents.

Graphical abstract: Built to bind: biosynthetic strategies for the formation of small-molecule protease inhibitors
From the themed collection: Emerging investigator Review series
Review Article

Michael additions in polyketide biosynthesis

Enzymes that catalyze a Michael-type addition in polyketide biosynthesis are summarized and discussed.

Graphical abstract: Michael additions in polyketide biosynthesis
From the themed collection: Emerging investigator Review series
5 items

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