Themed collection Prolines
Applications and future of ion mobility
mass spectrometry in structural biology
Ion mobility coupled to mass spectrometry (IMMS) separates gaseous ions on the basis of mass and structural properties. Hence, structural and dynamic information can be obtained for a wide variety of biomacromolecules.
Homooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigation
Homooligomers of substituted prolines and β-prolines were synthesized and studied using CD and NMR in water and alcohols.
Conformational properties of
peptides incorporating a fluorinated pseudoproline residue
Structural features of peptides incorporating one CF3-ΨPro residue were analyzed. A type-VI β-turn was observed in a short pseudotetrapeptide sequence.
proline analogues on the conformation of elastin peptides
Three elastin model peptides containing the repetitive motif –VGVXGVG–, where X corresponds to (2S)-proline (Pro), (2S,4R)-4-hydroxy-proline (Hyp) and (2S,4R)-4-methoxy-proline (Mop), were synthesized. The peptides were investigated at molecular and supramolecular levels.
Straightforward asymmetric synthesis of Ala-Ψ[CFCH]-Pro, a
proline-containing pseudodipeptide bearing a fluoroolefin as a peptide bond mimic
A new efficient asymmetric synthesis has been developed to obtain the relevant fluorinated pseudodipeptide Ala-Ψ[(Z)CFCH]-Pro.
About this collection
This themed collection in NJC brings an update on several issues surrounding the potential for prolines and related peptides. It aims to highlight the latest developments in the synthesis and structural elucidation of prolines and derivatives, as well as their biological activities.