Themed collection Graphene and 2D Materials in Healthcare

41 items
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Graphene-based biosensors for detecting coronavirus: a brief review

The coronavirus (SARS-CoV-2) disease has affected the globe with 770 437 327 confirmed cases, including about 6 956 900 deaths, according to the World Health Organization (WHO) as of September 2023.

Graphical abstract: Graphene-based biosensors for detecting coronavirus: a brief review
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Review Article

The potential of graphene coatings as neural interfaces

Graphene coatings hold transformative potential for brain interfaces. This review explores the physico-chemical aspects of chemical vapor deposited graphene coatings in neurological applications, highlighting the key properties of an ideal interface.

Graphical abstract: The potential of graphene coatings as neural interfaces
From the themed collection: Recent Review Articles
Review Article

Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches

New evidence for piezoelectric nanomaterials across energy harvesting, piezocatalysis, and biomedicine fields, guiding and supporting future drug delivery system development.

Graphical abstract: Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches
From the themed collection: Recent Review Articles
Open Access Review Article

Effects of mechanical properties of carbon-based nanocomposites on scaffolds for tissue engineering applications: a comprehensive review

Carbon-based nanocomposites are biodegradable and exhibit a low toxicity with mechanical properties due to carbon species. Mechanical properties, such as elasticity, tensile strength, elongation, and hardness are essential in tissue engineering.

Graphical abstract: Effects of mechanical properties of carbon-based nanocomposites on scaffolds for tissue engineering applications: a comprehensive review
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Review Article

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

The emergence of 2D nanomaterials, initiated by the graphene isolation in 2004, revolutionized various biomedical applications, including bioimaging, drug delivery and tissue engineering, due to their unique physicochemical and biological properties.

Graphical abstract: MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine
From the themed collection: Graphene and 2D Materials in Healthcare
Review Article

Enhancement of MXene optical properties towards medical applications via metal oxide incorporation

The integration of metal oxides into MXene structures has been instrumental in boosting high surface area, electrical conductivity, stability, and sensitivity. This points to a promising future for biomedical applications.

Graphical abstract: Enhancement of MXene optical properties towards medical applications via metal oxide incorporation
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Communication

Sources of biases in the in vitro testing of nanomaterials: the role of the biomolecular corona

A comparative journey into biomolecular corona features involving proteomics, lipidomics, high throughput in vitro screening, and molecular feature analysis to investigate the in vivo/in vitro bias for nanomaterials testing in biology.

Graphical abstract: Sources of biases in the in vitro testing of nanomaterials: the role of the biomolecular corona
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Communication

Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states

Graphene-based transistors (gSGFETs) enabled stable full-band brain recordings for 5+ months, allowing precise brain state identification and prediction, which is critical both in brain science and neurology.

Graphical abstract: Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Communication

Concurrent functional ultrasound imaging with graphene-based DC-coupled electrophysiology as a platform to study slow brain signals and cerebral blood flow under control and pathophysiological brain states

Graphene-enabled micro-transistor arrays can be used to improve our understanding of how infraslow brain signals relate to changes in cerebral blood flow.

Graphical abstract: Concurrent functional ultrasound imaging with graphene-based DC-coupled electrophysiology as a platform to study slow brain signals and cerebral blood flow under control and pathophysiological brain states
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Communication

MoS2 2D materials induce spinal cord neuroinflammation and neurotoxicity affecting locomotor performance in zebrafish

Upon ambient exposure, MoS2 nanomaterials can reach the nervous system of zebrafish larvae, resulting in a direct neurological damage characterized by neuroinflammation related cell alterations and behavioral abnormalities.

Graphical abstract: MoS2 2D materials induce spinal cord neuroinflammation and neurotoxicity affecting locomotor performance in zebrafish
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Communication

Detection of medically relevant volatile organic compounds with graphene field-effect transistors and separated by low-frequency spectral and time signatures

Separation of volatile organic compounds by spectral and time domain signatures measured using graphene field-effect transistor arrays in nitrogen carrying gas medium and correlated to the donor–acceptor number theory and low-frequency 1/f noise.

Graphical abstract: Detection of medically relevant volatile organic compounds with graphene field-effect transistors and separated by low-frequency spectral and time signatures
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Communication

Delivery of graphene oxide nanosheets modulates glutamate release and normalizes amygdala synaptic plasticity to improve anxiety-related behavior

Synaptic potentiation with increased dendritic spine density is a signature of fear memory consolidation in the lateral amygdala. Small graphene oxide reduces synaptic release and potentiation, preventing dendritic spine increase and fear behaviour.

Graphical abstract: Delivery of graphene oxide nanosheets modulates glutamate release and normalizes amygdala synaptic plasticity to improve anxiety-related behavior
From the themed collection: Graphene and 2D Materials in Healthcare
Communication

Small-artery-mimicking multi-layered 3D co-culture in a self-folding porous graphene-based film

We co-cultured endothelial and smooth muscle cells in a self-folding porous film to create a vessel-like in vitro model. The tunability of the geometries including curvature and pore size enables us to emulate the geometries of a small artery.

Graphical abstract: Small-artery-mimicking multi-layered 3D co-culture in a self-folding porous graphene-based film
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Communication

A graphene microelectrode array based microfluidic device for in situ continuous monitoring of biofilms

In situ continuous monitoring of bacterial biofilms has been a challenging job so far, but it is fundamental to the screening of novel anti-biofilm reagents.

Graphical abstract: A graphene microelectrode array based microfluidic device for in situ continuous monitoring of biofilms
From the themed collection: Graphene and 2D Materials in Healthcare
Communication

Colloidal gold-based immunochromatographic biosensor for quantitative detection of S100B in serum samples

A double antibody sandwich colloidal gold-based immunochromatographic biosensor for quantitative detection of S100B in serum.

Graphical abstract: Colloidal gold-based immunochromatographic biosensor for quantitative detection of S100B in serum samples
From the themed collection: Graphene and 2D Materials in Healthcare
Communication

A nanofluidic sensing platform based on robust and flexible graphene oxide/chitosan nanochannel membranes for glucose and urea detection

By combining chitosan, graphene oxide, and graphene quantum dots we developed reusable, flexible and compact nanofluidic membranes with “memory effect” that allows multiple cycles of pH-responsive urea/glucose detection.

Graphical abstract: A nanofluidic sensing platform based on robust and flexible graphene oxide/chitosan nanochannel membranes for glucose and urea detection
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Accepted Manuscript - Paper

An integrated design strategy coupling Additive Manufacturing and Matrix-Assisted Pulsed Laser Evaporation (MAPLE) towards the development of a new concept 3D scaffold with improved properties for Tissue Regeneration

From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Cytotoxicity assessment of exfoliated MoS2 using primary human mast cells and the progenitor cell-derived mast cell line LAD2

Assessment of the impact of molybdenum disulfide on immune cells (e.g., mast cells) is required to ascertain its biocompatibility in view of its future development for biomedical applications.

Graphical abstract: Cytotoxicity assessment of exfoliated MoS2 using primary human mast cells and the progenitor cell-derived mast cell line LAD2
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Graphene oxide activates canonical TGFβ signalling in a human chondrocyte cell line via increased plasma membrane tension

This study provides new insights into the molecular mechanisms underlying GO activated TGFβ signalling in chondrogenic cells. Contact with GO increased plasma membrane tension, activated mechanosensory pathways and endogenous TGFβ-1 as a mechanism for TGFβ signal activation.

Graphical abstract: Graphene oxide activates canonical TGFβ signalling in a human chondrocyte cell line via increased plasma membrane tension
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Intracellular biocompatible hexagonal boron nitride quantum emitters as single-photon sources and barcodes

Hexagonal boron nitride nanoparticles with color centers work as single-photon emitters from within live cells and enable robust photonic barcoding.

Graphical abstract: Intracellular biocompatible hexagonal boron nitride quantum emitters as single-photon sources and barcodes
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Surface modification of multilayer graphene electrodes by local printing of platinum nanoparticles using spark ablation for neural interfacing

Graphene electrode is coated with platinum nanoparticles using spark ablation to enhance the electrochemical characteristics of graphene for neural interfacing. The electrochemical stability of such coating is assessed indicating minimal deviation.

Graphical abstract: Surface modification of multilayer graphene electrodes by local printing of platinum nanoparticles using spark ablation for neural interfacing
From the themed collection: Graphene and 2D Materials in Healthcare
Paper

Crosstalk-free graphene–liquid elastomer based printed sensors for unobtrusive respiratory monitoring

Smart mask capable of determining respiratory profile at ambient and sub-zero conditions.

Graphical abstract: Crosstalk-free graphene–liquid elastomer based printed sensors for unobtrusive respiratory monitoring
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Few-layered graphene increases the response of nociceptive neurons to irritant stimuli

Few-layered graphene (FLG) treatment increases the functional response of the nociceptive subpopulation of sensory neurons of the dorsal root ganglia (DRG) in response to irritants specific for chemoreceptors TRPV1 and TRPA1.

Graphical abstract: Few-layered graphene increases the response of nociceptive neurons to irritant stimuli
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Interaction of graphene and WS2 with neutrophils and mesenchymal stem cells: implications for peripheral nerve regeneration

Graphene-based nerve conduits for peripheral nerve regeneration. Interaction with non-neuronal cell types: neutrophils and mesenchymal stem cells.

Graphical abstract: Interaction of graphene and WS2 with neutrophils and mesenchymal stem cells: implications for peripheral nerve regeneration
From the themed collection: Graphene and 2D Materials in Healthcare
Paper

Electrochemical impedance spectroscopy, another arrow in the arsenal to study the biodegradability of two-dimensional materials

Carbon nitrides represent an emerging class of two-dimensional materials exploited for energy storage, for catalysis, in composites, and in biomedicine. Their biodegradability has been studied under the conditions of the photo-Fenton reaction.

Graphical abstract: Electrochemical impedance spectroscopy, another arrow in the arsenal to study the biodegradability of two-dimensional materials
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Differences in interaction of graphene/graphene oxide with bacterial and mammalian cell membranes

Weak bonding among bacteria phospholipids and less repulsive force when graphene materials approach, result in graphene materials interacting differently with the bacteria compared to mammalian cells.

Graphical abstract: Differences in interaction of graphene/graphene oxide with bacterial and mammalian cell membranes
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Recording physiological and pathological cortical activity and exogenous electric fields using graphene microtransistor arrays in vitro

Full-band recordings, including infraslow components, were obtained with graphene SGFETs from cerebral cortex slices. First gSGFETs recordings from human tissue in vitro were obtained. gSGFETs were also used to quantify both exogenous and endogenous electric fields.

Graphical abstract: Recording physiological and pathological cortical activity and exogenous electric fields using graphene microtransistor arrays in vitro
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Synthetic graphene–copper nanocomposites interact with the hACE-2 enzyme and inhibit its biochemical activity

Graphene–Cu and copper oxide nanocomposites showed an enhanced inhibitory effect against the hACE-2 enzyme, which is one of the passages for COVID infection.

Graphical abstract: Synthetic graphene–copper nanocomposites interact with the hACE-2 enzyme and inhibit its biochemical activity
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Preclinical evaluation of modified carbon nanohorns and their complexation with insulin

Low toxicity in both in vitro and in vivo settings for carbon nanohorns modified with polyamidoamine was observed, and their complexation with insulin is accomplished.

Graphical abstract: Preclinical evaluation of modified carbon nanohorns and their complexation with insulin
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Nanostructured graphene oxide enriched with metallic nanoparticles as a biointerface to enhance cell adhesion through mechanosensory modifications

A graphene oxide nanofilm decorated with gold nanoparticles accelerated adhesion of cells by altering mechanotransduction and upregulating the expression of integrin α5β1, thus making it suitable for nanostructured coating for biomaterials.

Graphical abstract: Nanostructured graphene oxide enriched with metallic nanoparticles as a biointerface to enhance cell adhesion through mechanosensory modifications
From the themed collection: Graphene and 2D Materials in Healthcare
Paper

Anticancer and antibacterial properties of carbon nanotubes are governed by their functional groups

Carbon nanotubes with carbon atoms at a +3 oxidation number easily translocate through the cell membrane. With cytotoxicity towards macrophages at 10%, cancer cell number is reduced by up to 59% and bacterial colonization – by up to 99%.

Graphical abstract: Anticancer and antibacterial properties of carbon nanotubes are governed by their functional groups
From the themed collection: Graphene and 2D Materials in Healthcare
Paper

Coal waste-derived synthesis of yellow oxidized graphene quantum dots with highly specific superoxide dismutase activity: characterization, kinetics, and biological studies

The remediation of coal waste into YGQDs with SOD-specific activity and superoxide ion binding in nanomolar range is reported for the first time. The molecular mechanism of its antioxidative and antiapoptotic properties are confirmed in C6-cells.

Graphical abstract: Coal waste-derived synthesis of yellow oxidized graphene quantum dots with highly specific superoxide dismutase activity: characterization, kinetics, and biological studies
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

One-year post-exposure assessment of 14C-few-layer graphene biodistribution in mice: single versus repeated intratracheal administration

Long-term investigation of the biodistribution of 14C-few-layer graphene after tracheal administration: repeated vs. single exposure.

Graphical abstract: One-year post-exposure assessment of 14C-few-layer graphene biodistribution in mice: single versus repeated intratracheal administration
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Two-dimensional molybdenum disulfide nanosheets evoke nitric oxide-dependent antibacterial effects

This study shows that 2D MoS2 nanosheets display cellular and acellular (enzyme mimetic) antibacterial effects.

Graphical abstract: Two-dimensional molybdenum disulfide nanosheets evoke nitric oxide-dependent antibacterial effects
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Effects of graphene oxide and reduced graphene oxide nanomaterials on porcine endothelial progenitor cells

Effects of GO and rGO nanomaterials on porcine endothelial progenitor cells.

Graphical abstract: Effects of graphene oxide and reduced graphene oxide nanomaterials on porcine endothelial progenitor cells
From the themed collection: Graphene and 2D Materials in Healthcare
Paper

Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS2-powered MCF-7 cancer cell sensors

We control the electrical character of a 2D nanomaterial by using the integration of the phage-conjugated polymer and the nanosheet through shape-complementarity processes and design a sensor system for the rapid, sensitive detection of MCF-7 cells.

Graphical abstract: Shape complementarity processes for ultrashort-burst sensitive M13–PEG–WS2-powered MCF-7 cancer cell sensors
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Covalent functionalisation controlled by molecular design for the aptameric recognition of serotonin in graphene-based field-effect transistors

This work introduces a controlled covalent functionalization using molecular design and electrochemical triggering, enabling monolayer-like functionalization of GFET while preserving graphene's electronic properties for monitoring of serotonin.

Graphical abstract: Covalent functionalisation controlled by molecular design for the aptameric recognition of serotonin in graphene-based field-effect transistors
From the themed collection: Graphene and 2D Materials in Healthcare
Paper

Background-filtered telomerase activity assay with cyclic DNA cleavage amplification

A new telomerase activity detection method termed Quenching-Exempt invader Signal Amplification Test (QUEST) is developed.

Graphical abstract: Background-filtered telomerase activity assay with cyclic DNA cleavage amplification
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Efficient skin interactions of graphene derivatives: challenge, opportunity or both?

Positively and negatively charged graphene sheets interacted with human skin and enhanced penetration of Nile red-loaded into the epidermal and dermal layers of the skin. Moreover, graphene's cargo was released more efficiently into the skin layers after laser exposure.

Graphical abstract: Efficient skin interactions of graphene derivatives: challenge, opportunity or both?
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

In vitro assessment of skin irritation and corrosion properties of graphene-related materials on a 3D epidermis

Graphene-related materials are not skin corrosive and, if containing low surfactant residues, not skin irritant, as assessed on a 3D model of skin epidermis using the relevant OECD test guidelines.

Graphical abstract: In vitro assessment of skin irritation and corrosion properties of graphene-related materials on a 3D epidermis
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Mimicking the extracellular matrix by incorporating functionalized graphene into hybrid hydrogels

The efficient functionalization of graphene with sulfonic groups facilitates the interaction of biomolecules with the hydrogel surface. An enhancement on the viscoelasticity and cell development was observed in the hybrid-sulfonic graphene hydrogels.

Graphical abstract: Mimicking the extracellular matrix by incorporating functionalized graphene into hybrid hydrogels
From the themed collection: Graphene and 2D Materials in Healthcare
41 items

About this collection

Over the past decade, the Graphene Flagship Division II (Health, Medicine, Sensors) has contributed immensely to developments in graphene-based technologies for biomedical applications, safe and sustainable graphene and related materials, and high-performance sensors with a variety of applications, from detecting disease biomarkers, to piezoresistive devices for microphones and speakers. This collection coincides with the celebration of the achievements and completion of this programme of work. Guest Edited by Prof Laura Ballerini (Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy), Dr Alberto Bianco (CNRS Strasbourg, France), Prof Kostas Kostarelos (University of Manchester, United Kingdom, and Catalan Institute of Nanoscience & Nanotechnology (ICN2), Barcelona, Spain) and Prof Maurizio Prato (CIC biomaGUNE, San Sebastián, Spain), this collection features research from participants in the Graphene Flagship programme as well as other investigators working in these important research areas at institutions outside of the Flagship.

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