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Themed collection Metallomics Recent Open Access Articles

20 items
Open Access Perspective

Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging

Taking a systems analytical approach to systems biology questions requires a network of multidimensional analytical tools to illuminate the many different functional and structural aspects of metals in biology.

Graphical abstract: Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging
From the themed collection: Metallomics Recent Open Access Articles
Open Access Minireview

Is copper a new target to counteract the progression of chronic diseases?

In this review, we highlight the importance of a Cu imbalance in the pathogenesis of several chronic inflammatory diseases.

Graphical abstract: Is copper a new target to counteract the progression of chronic diseases?
From the themed collection: Metallomics Recent Open Access Articles
Open Access Communication

First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro

ICD enhances antigenicity from dying cancer cells, which leads to antitumor immunity. We show for the first time that a ruthenium-complex induces the ICD signature in a 3D model.

Graphical abstract: First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro
From the themed collection: Metallomics Recent Open Access Articles
Open Access Communication

Interaction of Cu(I) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features

Coordination environment and conformational consequences of Cu(I) binding at Met-X3-Met site of AcαS.

Graphical abstract: Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Chemical imaging and assessment of cadmium distribution in the human body

Adipose and muscle tissue – so far underestimated – contribute to the total Cd burden. Cd distribution in testis and kidney correlates with the histologic blood-testis-barrier and renal excretion, respectively.

Graphical abstract: Chemical imaging and assessment of cadmium distribution in the human body
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells

Interdisciplinary study of the cellular transport and metabolism of the organo-osmium complex FY26 in cancer cells towards its clinical development.

Graphical abstract: Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics

Resistance development is a major obstacle for platinum-based chemotherapy, with the anticancer drug oxaliplatin being no exception.

Graphical abstract: Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer

Zinc transporter ZIP7 activates key downstream signalling pathways and is correlated with important clinicopathological parameters that are associated with endocrine resistance.

Graphical abstract: Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Copper relay path through the N-terminus of Wilson disease protein, ATP7B

Using a yeast assay, we identified the roles of ATP7B's six metal-binding domains in internal copper transport and soluble chaperone capacity.

Graphical abstract: Copper relay path through the N-terminus of Wilson disease protein, ATP7B
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma

Targeting the Cu chaperone ATOX1 in BRAFV600E-driven melanoma dampens cell growth due in part by reducing oncogenic MAPK signal transduction.

Graphical abstract: Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

The pivotal role of MBD4–ATP7B in the human Cu(I) excretion path as revealed by EPR experiments and all-atom simulations

Atox1–MBD4 interaction mediates the in-cell Cu(I) concentration.

Graphical abstract: The pivotal role of MBD4–ATP7B in the human Cu(i) excretion path as revealed by EPR experiments and all-atom simulations
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Dynamic homeostasis modeling of Zn isotope ratios in the human body

Recent research performed on volunteers and patients suggested that diet, health, and basal metabolic rates (BMR) are factors controlling the bodily Zn isotope compositions (isotopic homeostasis).

Graphical abstract: Dynamic homeostasis modeling of Zn isotope ratios in the human body
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Lanthanides compete with calcium for binding to cadherins and inhibit cadherin-mediated cell adhesion

Substitutions with lanthanides reveal a high sensitivity of cadherin structure, dynamics and function to metal ion chemistry.

Graphical abstract: Lanthanides compete with calcium for binding to cadherins and inhibit cadherin-mediated cell adhesion
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A

Friendreich's ataxia skin cells are highly sensitive to ultraviolet A due to their high levels of mitochondrial redox-active iron.

Graphical abstract: The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum

Dinuclear ruthenium complexes inhibit N. caninum and specifically target the parasite mitochondria.

Graphical abstract: Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Induced CD of iron(II) clathrochelates: sensing of the structural and conformational alterations of serum albumins

Iron(II) clathrochelates are protein-sensitive CD reporters able to discriminate proteins of similar structure (HSA and BSA) and reflect the transitions of protein conformation.

Graphical abstract: Induced CD of iron(ii) clathrochelates: sensing of the structural and conformational alterations of serum albumins
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism

Pathogenic Staphylococcus aureus respond to copper stress by altering central carbon metabolism in response to a specific inhibition of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase.

Graphical abstract: Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus

X-ray fluorescence microscopy reveals unique elemental signatures within sub-populations of hippocampal pyramidal neurons.

Graphical abstract: Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Iron-sensing is governed by mitochondrial, not by cytosolic iron–sulfur cluster biogenesis in Aspergillus fumigatus

Microorganisms have to adapt their metabolism to the requirements of their ecological niche to avoid iron shortage as well as iron toxicity.

Graphical abstract: Iron-sensing is governed by mitochondrial, not by cytosolic iron–sulfur cluster biogenesis in Aspergillus fumigatus
From the themed collection: Metallomics Recent Open Access Articles
Open Access Paper

Metallothioneins of the urochordate Oikopleura dioica have Cys-rich tandem repeats, large size and cadmium-binding preference

Oikopleura dioica has the longest metallothionein described so far, made of repeats generated by a modular and step-wise evolution.

Graphical abstract: Metallothioneins of the urochordate Oikopleura dioica have Cys-rich tandem repeats, large size and cadmium-binding preference
From the themed collection: Metallomics Recent Open Access Articles
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This collection features recent open access articles published in Metallomics.

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