Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging
Taking a systems analytical approach to systems biology questions requires a network of multidimensional analytical tools to illuminate the many different functional and structural aspects of metals in biology.
Is copper a new target to counteract the progression of chronic diseases?
In this review, we highlight the importance of a Cu imbalance in the pathogenesis of several chronic inflammatory diseases.
First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro
ICD enhances antigenicity from dying cancer cells, which leads to antitumor immunity. We show for the first time that a ruthenium-complex induces the ICD signature in a 3D model.
Interaction of Cu(I) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features
Coordination environment and conformational consequences of Cu(I) binding at Met-X3-Met site of AcαS.
Chemical imaging and assessment of cadmium distribution in the human body
Adipose and muscle tissue – so far underestimated – contribute to the total Cd burden. Cd distribution in testis and kidney correlates with the histologic blood-testis-barrier and renal excretion, respectively.
Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells
Interdisciplinary study of the cellular transport and metabolism of the organo-osmium complex FY26 in cancer cells towards its clinical development.
Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics
Resistance development is a major obstacle for platinum-based chemotherapy, with the anticancer drug oxaliplatin being no exception.
Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer
Zinc transporter ZIP7 activates key downstream signalling pathways and is correlated with important clinicopathological parameters that are associated with endocrine resistance.
Copper relay path through the N-terminus of Wilson disease protein, ATP7B
Using a yeast assay, we identified the roles of ATP7B's six metal-binding domains in internal copper transport and soluble chaperone capacity.
Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma
Targeting the Cu chaperone ATOX1 in BRAFV600E-driven melanoma dampens cell growth due in part by reducing oncogenic MAPK signal transduction.
The pivotal role of MBD4–ATP7B in the human Cu(I) excretion path as revealed by EPR experiments and all-atom simulations
Atox1–MBD4 interaction mediates the in-cell Cu(I) concentration.
Dynamic homeostasis modeling of Zn isotope ratios in the human body
Recent research performed on volunteers and patients suggested that diet, health, and basal metabolic rates (BMR) are factors controlling the bodily Zn isotope compositions (isotopic homeostasis).
Lanthanides compete with calcium for binding to cadherins and inhibit cadherin-mediated cell adhesion
Substitutions with lanthanides reveal a high sensitivity of cadherin structure, dynamics and function to metal ion chemistry.
The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A
Friendreich's ataxia skin cells are highly sensitive to ultraviolet A due to their high levels of mitochondrial redox-active iron.
Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum
Dinuclear ruthenium complexes inhibit N. caninum and specifically target the parasite mitochondria.
Induced CD of iron(II) clathrochelates: sensing of the structural and conformational alterations of serum albumins
Iron(II) clathrochelates are protein-sensitive CD reporters able to discriminate proteins of similar structure (HSA and BSA) and reflect the transitions of protein conformation.
Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism
Pathogenic Staphylococcus aureus respond to copper stress by altering central carbon metabolism in response to a specific inhibition of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase.
Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus
X-ray fluorescence microscopy reveals unique elemental signatures within sub-populations of hippocampal pyramidal neurons.
Iron-sensing is governed by mitochondrial, not by cytosolic iron–sulfur cluster biogenesis in Aspergillus fumigatus
Microorganisms have to adapt their metabolism to the requirements of their ecological niche to avoid iron shortage as well as iron toxicity.
Metallothioneins of the urochordate Oikopleura dioica have Cys-rich tandem repeats, large size and cadmium-binding preference
Oikopleura dioica has the longest metallothionein described so far, made of repeats generated by a modular and step-wise evolution.
About this collection
This collection features recent open access articles published in Metallomics.