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Themed collection Metal Toxicity

21 items
Cover

Front cover

Graphical abstract: Front cover
From the themed collection: Metal Toxicity
Front/Back Matter

Inside front cover

Graphical abstract: Inside front cover
From the themed collection: Metal Toxicity
Front/Back Matter

Contents list

From the themed collection: Metal Toxicity
Editorial

Metal toxicity

This editorial introduces the Metal Toxicity themed issue, guest edited by Gregor Grass (left) and Christopher Rensing (right).

Graphical abstract: Metal toxicity
From the themed collection: Metal Toxicity
Minireview

Copper toxicity and the origin of bacterial resistance—new insights and applications

The development of copper resistance is put into an evolutionary context. Possible use of copper in innate immunity and protozoan predation is also discussed. Finally, the antimicrobial properties of copper surfaces are summarized.

Graphical abstract: Copper toxicity and the origin of bacterial resistance—new insights and applications
From the themed collection: Metal Toxicity
Minireview

Genetic and epigenetic effects of environmental arsenicals

Environmental arsenicals and their methylated metabolites have the capacity to induce genome destabilizing and epigenetic effects in cells and in vivo.

Graphical abstract: Genetic and epigenetic effects of environmental arsenicals
From the themed collection: Metal Toxicity
Minireview

Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance

A speculative graphical abstract of how Co2+ ions could exert their toxic effect in interfering with Fe-S cluster biogenesis.

Graphical abstract: Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance
From the themed collection: Metal Toxicity
Minireview

Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence

This review highlights the structural, mechanistic, and physiological differences between the two super-families of ATP-driven transition metal transport systems.

Graphical abstract: Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence
From the themed collection: Most accessed Metallomics articles
Minireview

Chromate toxicity and the role of sulfur

We discuss how Cr exposure causes sulfur depletion in cells and that this may underpin key aspects of Cr toxicity.

Graphical abstract: Chromate toxicity and the role of sulfur
From the themed collection: Metal Toxicity
Minireview

The oxidative stress of zinc deficiency

This minireview describes the possible sources of oxidative stress in zinc-limited cells and mechanisms cells use to overcome that stress.

Graphical abstract: The oxidative stress of zinc deficiency
From the themed collection: Metal Toxicity
Critical Review

Metabolomics and its application to studying metal toxicity

This review explores the use of metabolomics to study metal toxicity, an unexplored topic in the literature.

Graphical abstract: Metabolomics and its application to studying metal toxicity
From the themed collection: Metal Toxicity
Critical Review

Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases

Pathogenesis of several neurodegenerative diseases is associated with intrinsically disordered proteins that interact with metals, misfold, and aggregate.

Graphical abstract: Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
From the themed collection: Metal Toxicity
Critical Review

Toxic elements in tobacco and in cigarette smoke: inflammation and sensitization

This review summarizes available evidence related to selected health risks from metals or metalloid exposures from particulate inhalation and oral exposure.

Graphical abstract: Toxic elements in tobacco and in cigarette smoke: inflammation and sensitization
From the themed collection: Metal Toxicity
Critical Review

Mechanisms of nickel toxicity in microorganisms

Nickel inhibits microbial enzymes (substituting for the normal metal or binding to catalytic/secondary sites) and indirectly creates reactive oxygen species.

Graphical abstract: Mechanisms of nickel toxicity in microorganisms
From the themed collection: Nickel in biology
Paper

The chemical forms of mercury and selenium in whale skeletal muscle

X-ray absorption spectroscopy is used to investigate the comparative chemical forms of mercury and selenium in fish and whale skeletal muscle.

Graphical abstract: The chemical forms of mercury and selenium in whale skeletal muscle
From the themed collection: Metal Toxicity
Paper

The C2H2 zinc finger transcription factors are likely targets for Ni(II) toxicity

C2H2 zinc fingers of many transcription factors are susceptible to hydrolytic damage by Ni(II) ions without Zn(II) displacement.

Graphical abstract: The C2H2 zinc finger transcription factors are likely targets for Ni(ii) toxicity
From the themed collection: Metal Toxicity
Paper

Modeling the cellular impact of nanoshell-based biosensors using mouse alveolar macrophage cultures

Investigation into the toxicity of gold-silica nanoshells based on changes to surface chemistry, dose time, and concentration using macrophage cells.

Graphical abstract: Modeling the cellular impact of nanoshell-based biosensors using mouse alveolar macrophage cultures
From the themed collection: Metal Toxicity
Paper

Zinc, cadmium and nickel increase the activation of NF-κB and the release of cytokines from THP-1 monocytic cells

Zinc, nickel and cadmium have a pro-inflammatory effect on THP-1 monocytic cells.

Graphical abstract: Zinc, cadmium and nickel increase the activation of NF-κB and the release of cytokines from THP-1 monocytic cells
From the themed collection: Metal Toxicity
Paper

Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion

Compared with soluble platinum compounds, cellular influences of physically and chemically inactive platinum nanoparticles were small.

Graphical abstract: Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion
From the themed collection: Metal Toxicity
Paper

Responses of human cells to ZnO nanoparticles: a gene transcription study

NanoZnO contact elicits a unfolded protein transcriptional response compared to inert nanoTiO2.

Graphical abstract: Responses of human cells to ZnO nanoparticles: a gene transcription study
From the themed collection: Metal Toxicity
Paper

Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice

A co-administration regimen of cisplatin plus N-glucosyl-N-dithiocarbamateamino acid disodium compounds was explored and has been shown to improve the therapy of S180-bearing mice for the first time.

Graphical abstract: Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice
From the themed collection: Metal Toxicity
21 items

About this collection

Guest Edited by Chris Rensing of the University of Arizona and Gregor Grass of the Bundeswehr Institute of Microbiology, this issue contains a collection of reviews and research papers highlighting an important aspect of metal biology.

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