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Themed collection In memory of Silvia Atrian

19 items
Editorial

Goodbye to Silvia Atrian

Mercè Capdevila and Òscar Palacios, longtime collaborators and friends of Silvia Atrian, reflect on Silvia's impact on the field of metallomics, as highlighted in a collection of papers published in Metallomics.

Graphical abstract: Goodbye to Silvia Atrian
From the themed collection: In memory of Silvia Atrian
Open Access Perspective

Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(II), and Cd–metallothionein complexes

The toxicity of cadmium during pregnancy and lactation causes low zinc levels, metallothionein changes and materno-fetal and newborn alterations.

Graphical abstract: Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(ii), and Cd–metallothionein complexes
From the themed collection: Recent Review Articles
Minireview

The complex global response to copper in the multicellular bacterium Myxococcus xanthus

Mechanism of action of CorE, a metal-dependent ECF σ factor.

Graphical abstract: The complex global response to copper in the multicellular bacterium Myxococcus xanthus
From the themed collection: Recent Review Articles
Critical Review

Metallothionein diversity and distribution in the tree of life: a multifunctional protein

Metallothioneins are diverse, but not represented yet in all phyla. Moreover, they play a central role as a [MT:T:TO] protein system.

Graphical abstract: Metallothionein diversity and distribution in the tree of life: a multifunctional protein
From the themed collection: Recent Review Articles
Open Access Communication

Interaction of Cu(I) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features

Coordination environment and conformational consequences of Cu(I) binding at Met-X3-Met site of AcαS.

Graphical abstract: Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features
From the themed collection: Metallomics Recent HOT articles
Paper

Pb(II) binding to the brain specific mammalian metallothionein isoform MT3 and its isolated αMT3 and βMT3 domains

MT3 can bind Pb2+ to form a variety of metallated Pb-MT3 species.

Graphical abstract: Pb(ii) binding to the brain specific mammalian metallothionein isoform MT3 and its isolated αMT3 and βMT3 domains
From the themed collection: In memory of Silvia Atrian
Open Access Paper

Induced CD of iron(II) clathrochelates: sensing of the structural and conformational alterations of serum albumins

Iron(II) clathrochelates are protein-sensitive CD reporters able to discriminate proteins of similar structure (HSA and BSA) and reflect the transitions of protein conformation.

Graphical abstract: Induced CD of iron(ii) clathrochelates: sensing of the structural and conformational alterations of serum albumins
From the themed collection: In memory of Silvia Atrian
Paper

Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE

Mice treated daily with MT2 (but not MT1) showed a significant amelioration of the clinical course of experimental autoimmune encephalomyelitis (EAE).

Graphical abstract: Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE
From the themed collection: Metallomics Recent HOT articles
Paper

Computational insight into the interaction of oxaliplatin with insulin

Multiscale theoretical approach predicts the binding of oxaliplatin to insulin and its implications in conformational changes implying potential effects on the biological functions of the protein.

Graphical abstract: Computational insight into the interaction of oxaliplatin with insulin
From the themed collection: In memory of Silvia Atrian
Open Access Paper

Molecular genetic and biochemical characterization of a putative family of zinc metalloproteins in Caenorhabditis elegans

The first characterization of W08E12.2, W08E12.3, W08E12.4 and W08E12.5, four putative metalloproteins in C. elegans. (A) phase contrast microscopy, (B) fluorescence microscopy of PW08E12.3;W08E12.4::GFP.

Graphical abstract: Molecular genetic and biochemical characterization of a putative family of zinc metalloproteins in Caenorhabditis elegans
From the themed collection: In memory of Silvia Atrian
Paper

Non-coordinative metal selectivity bias in human metallothioneins metal–thiolate clusters

Mammalian metallothioneins MT-2 and MT-3 contain two metal–thiolate clusters through cysteine coordination of d10 metals, Cu(I) and Zn(II), and isoform-specific non-coordinating residues control their respective zinc– and copper–thionein character.

Graphical abstract: Non-coordinative metal selectivity bias in human metallothioneins metal–thiolate clusters
From the themed collection: In memory of Silvia Atrian
Paper

Analysis of the soybean metallothionein system under free radical stress: protein modification connected to lipid membrane damage

Metal clusters act as good interceptors of free radicals for four plant metallothioneins: partial deconstruction, structural rearrangement and damage transfer to cell membranes.

Graphical abstract: Analysis of the soybean metallothionein system under free radical stress: protein modification connected to lipid membrane damage
From the themed collection: In memory of Silvia Atrian
Paper

Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+ binding?

Polyhistidine triad proteins (with multiple copies of the HxxHxH sequence), which participate in Zn2+ uptake in Streptococcus pneumoniae, are also efficient Ni2+ binders.

Graphical abstract: Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+ binding?
From the themed collection: In memory of Silvia Atrian
Paper

Metal binding functions of metallothioneins in the slug Arion vulgaris differ from metal-specific isoforms of terrestrial snails

Arion vulgaris is a European slug with a huge potential for accumulating and detoxifying heavy metals.

Graphical abstract: Metal binding functions of metallothioneins in the slug Arion vulgaris differ from metal-specific isoforms of terrestrial snails
From the themed collection: In memory of Silvia Atrian
Open Access Paper

Metallothioneins of the urochordate Oikopleura dioica have Cys-rich tandem repeats, large size and cadmium-binding preference

Oikopleura dioica has the longest metallothionein described so far, made of repeats generated by a modular and step-wise evolution.

Graphical abstract: Metallothioneins of the urochordate Oikopleura dioica have Cys-rich tandem repeats, large size and cadmium-binding preference
From the themed collection: In memory of Silvia Atrian
Paper

The type 4 metallothionein from Brassica napus seeds folds in a metal-dependent fashion and favours zinc over other metals

Rapeseed MT4 only folds properly in the presence of Zn2+ and thus may serve as a selectivity filter for metal accumulation in plant embryos.

Graphical abstract: The type 4 metallothionein from Brassica napus seeds folds in a metal-dependent fashion and favours zinc over other metals
From the themed collection: Metallomics Recent HOT articles
Paper

A histidine-rich Pseudomonas metallothionein with a disordered tail displays higher binding capacity for cadmium than zinc

The NMR solution structure of a Pseudomonas metallothionein reveals a different binding capacity for ZnII and CdII ions that results in two novel metal-cluster topologies. Replacement of a non-coordinating residue by histidine decreases the kinetic lability of the cluster. All three structures reported show an identical protein fold.

Graphical abstract: A histidine-rich Pseudomonas metallothionein with a disordered tail displays higher binding capacity for cadmium than zinc
From the themed collection: Metallomics Recent HOT articles
Paper

Molecular strategies to increase yeast iron accumulation and resistance

The expression of the constitutive Saccharomyces cerevisiae Aft1-1UP transcription factor increases iron accumulation, oxidative stress and iron-sensitivity, but diminishes oxygen consumption.

Graphical abstract: Molecular strategies to increase yeast iron accumulation and resistance
From the themed collection: In memory of Silvia Atrian
Open Access Paper

Short oligopeptides with three cysteine residues as models of sulphur-rich Cu(I)- and Hg(II)-binding sites in proteins

Peptides mimicking sulphur-rich fragments found in metallothioneins display unexpectedly different behaviours with the two metal ions Hg(II) and Cu(I).

Graphical abstract: Short oligopeptides with three cysteine residues as models of sulphur-rich Cu(i)- and Hg(ii)-binding sites in proteins
From the themed collection: In memory of Silvia Atrian
19 items

About this collection

Silvia Atrian made numerous valuable contributions to the scientific community. Her insightful work exploring the metal binding abilities of metallothioneins in many species, which lead to a new classification proposal aimed at understanding their functionality, has helped bring clarity to a complex set of questions. In addition to her work, she will be remembered by members of the community for her generosity of spirit and her willingness to work with and help others in the field.

Guest Edited by her long-time collaborator Mercè Capdevila, we hope that this collection of papers in Metallomics will be a fitting memorial to an inspiring mentor and outstanding scientist.


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