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Metallomics in Japan
This editorial updates the Metallomics in Japan theme issue series in Metallomics. Guest edited by Yasumitsu Ogra and Seiichiro Himeno it presents papers originating from the 3rd Metallomics Research Forum in Japan held on 30-31 August 2012 at Showa Pharmaceutical University, Tokyo.
Synaptic Zn2+ homeostasis and its significance
The decrease in serum zinc is linked to the hypothalamic–pituitary–adrenal (HPA) axis activation that increases the serum glucocorticoid level, indicating the importance of zinc homeostasis in physiological function.
A coupling system of capillary gel electrophoresis with inductively coupled plasma-mass spectrometry for the determination of double stranded DNA fragments
The coupling system of capillary gel electrophoresis (CGE) and inductively coupled plasma-mass spectrometry (ICP-MS) was newly developed and successfully applied to the double-stranded (ds) DNA quantification.
Scanning protein analysis of electrofocusing gels using X-ray fluorescence
Scanning protein analysis using synchrotron radiation excited X-ray fluorescence (SPAX) can provide 2-D information regarding the concentrations of elements in freeze-dried electrofocusing gels.
Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells
Cd-resistant and Mn-resistant cells established from RBL-2H3 cells showed the suppression of ZIP8 which is involved in the transport of both Cd and Mn.
Selenium metabolism and excretion in mice after injection of 82Se-enriched selenomethionine
Time-dependent changes of 82Se incorporated into selenoproteins (Sel-P and cGPx) in mice were investigated after intravenous injection of 82SeMet.
Synthesis of antitumor azolato-bridged dinuclear platinum(II) complexes with in vivo antitumor efficacy and unique in vitro cytotoxicity profiles
5-R-tetrazolato-bridged dinuclear Pt(II) complexes exhibited marked antitumor efficiency when tested in vivo on xenografts of PANC-1 pancreatic cancer in nude mice.
AMP-activated protein kinase-mediated glucose transport as a novel target of tributyltin in human embryonic carcinoma cells
Organotin compounds such as tributyltin (TBT) are known to cause various forms of cytotoxicity, including developmental toxicity and neurotoxicity.
D-Histidine and L-histidine attenuate zinc-induced neuronal death in GT1-7 cells
Although zinc (Zn) is an essential trace element, excess Zn causes neuronal death following transient global ischemia and plays a central role in the pathogenesis of vascular-type dementia.
Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice
Dietary selenium-deficiency causes elevation of amyloid-β plaque deposition in the brain of Tg2576 transgenic mice.
The role of glutathione in the metabolism of diphenylarsinic acid in rats
Diphenylarsinic acid (DPAAV) is converted in the rat to the trivalent DPAA–GSH complex (DPAG), and DPAIII, the hydrolytic product of DPAG, binds to proteins.
Analysis of animal and plant selenometabolites in roots of a selenium accumulator, Brassica rapa var. peruviridis, by speciation
Se-accumulating plants can metabolize the organic selenometabolites of animals and plants.
About this collection
Updates the Metallomics in Japan theme issue series and present papers originating from the 3rd Metallomics Research Forum in Tokyo, Japan, 2012.