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Themed collection Neurochemistry of lead and manganese

8 items
Editorial

Neurochemistry of lead and manganese

Rachel Austin, Jennifer Freeman and Tomás Guilarte introduce this themed issue of Metallomics, on the neurochemistry of lead and manganese.

Graphical abstract: Neurochemistry of lead and manganese
From the themed collection: Neurochemistry of lead and manganese
Minireview

Defining potential roles of Pb2+ in neurotoxicity from a calciomics approach

Metal ions play crucial roles in numerous biological processes, facilitating biochemical reactions by binding to various proteins.

Graphical abstract: Defining potential roles of Pb2+ in neurotoxicity from a calciomics approach
From the themed collection: Metallomics Recent HOT articles
Critical Review

Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health

This critical review focuses on one possible link between the cellular biology of lead and its neurotoxic effects: the link between Pb2+ substitution for Zn2+ in zinc-finger proteins and mental illness in adulthood.

Graphical abstract: Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health
From the themed collection: Metallomics Recent HOT articles
Paper

Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure

HFE H67D mutation up-regulates ferroportin, a metal exporter for manganese (Mn) and iron, and reduces Mn accumulation in the striatum after olfactory exposure to Mn, which consequently decreases Mn-induced oxidative stress in the brain.

Graphical abstract: Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure
From the themed collection: Neurochemistry of lead and manganese
Open Access Paper

Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing

A report on lead and manganese in serum and erythrocytes in one of the world's largest Alzheimer's disease cohorts.

Graphical abstract: Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing
From the themed collection: Alzheimer's Research Month 2016
Paper

Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese

Mn induces short- and long-term alterations on striatal tyrosine hydroxylase levels and phosphorylation in rats.

Graphical abstract: Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese
From the themed collection: Neurochemistry of lead and manganese
Paper

Embryonic exposure to 10 μg L−1 lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain

Embryonic exposure to Pb at levels as low as 10 μg L−1 disturb global gene expression patterns in a sex-specific manner.

Graphical abstract: Embryonic exposure to 10 μg L−1 lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain
From the themed collection: Alzheimer's Research Month 2016
Paper

Thermodynamics of Pb(II) and Zn(II) binding to MT-3, a neurologically important metallothionein

The first quantification of Pb(II) binding to MT-3 using ITC shows that lead binds more tightly than zinc to this brain-specific metallothionein.

Graphical abstract: Thermodynamics of Pb(ii) and Zn(ii) binding to MT-3, a neurologically important metallothionein
From the themed collection: Zinc in the Biosciences
8 items

About this collection

This themed issue, Guest Edited by Professor Rachel Austin, Professor Jennifer Freeman and Professor Tomas Guilarte, highlights the molecular mechanisms by which lead and manganese impact the central nervous system.

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