Minireview
Engineering the interaction of short antimicrobial peptides with bacterial barriers
Designing short antimicrobial peptides and tuning their interaction with bacterial barriers.
Recent advances in 3D bioprinting of polysaccharide-based bioinks for fabrication of bioengineered tissues
Complex multilayered tissues have been regenerated by extrusion-based 3D bioprinting with biocompatible polymers. Multilayer fabrications with tissue-specific bioinks are possible by controlling gel properties including interaction between layers.
Fabrication of a photothermal antibacterial platform for bacterial infectious skin wound healing: a review
Antibiotics are the main strategy to treat bacterial infections, but can cause bacterial resistance. We comprehensively summarize work on the fabrication of photothermal antibacterial platforms for bacterial infectious skin wound healing.
Review Article
Enhancing enzymatic activity with nanoparticle display – an updated compendium and engineering outlook
Schematic depicting enzyme kinetic enhancement when displayed on a nanoparticle surface. We provide a state of the art review of this phenomenon describing what is known about how it arises along with examples grouped by nanomaterials.
Design and engineering of an artificial disulfide bond in human cytochrome c to regulate the protein structure and function
An artificial disulfide bond was rationally constructed in human cytochrome c (hCyt c) via double mutations (A51C/G77C), which weakened the coordination of Met80 to the heme iron and enhanced the peroxidase activity of hCyt c.
Paper
Optimization of chondroitin production in E. coli using genome scale models
E. coli was used to produce chondroitin both in silico and in vivo, marking the first use of genome-scale metabolic models to predict its production. Identified targets can guide future works towards more efficient hosts for chondroitin production.
Formation mechanism of anisotropic gelatin hydrogel by self-assembly on oriented templates
The development of structurally controlled techniques inspired by the structural formation of living systems is of great importance for the fabrication of next-generation functional soft materials using environmentally friendly processes.
Supramolecular assembly of multifunctional protein gels via an N-glycosylation consensus sequence fusion domain
Stimuli-responsive polypeptide tags direct the assembly of active proteins into supramolecular assemblies. This allows for recombinant expression of soluble fusion protein and subsequent user-controlled formation of functional biomaterials.
Liquid metal–polymer nano-microconjugations as an injectable and photo-activatable drug carrier
Nanoparticles of photoresponsive liquid–liquid phase-separation polymers complexed with liquid metals can concentrate drugs upon photoirradiation, opening up new DDS horizons.
Paper
A physics-inspired approach to the understanding of molecular representations and models
By drawing on similarities between energy landscapes and model response surfaces we gain new insight into model performance, even in the absence of data.
Paper
Cancer-targeting gold-decorated melanin nanoparticles for in vivo near-infrared photothermal therapy
Melanin-like nanoparticles decorated with gold nanoparticles are presented as cancer-targeting near-infrared (NIR) photothermal agents with excellent photothermal conversion and stability.
Paper
On the use of modelling antagonistic enzymes to aid in temporal programming of pH and PVA–borate gelation
A model was developed to help predict how enzymes can be used to temporally control the gelation of polyvinyl alcohol (PVA) with borate.
Light-activation of molecular motors in polymersomes
Light-activated molecular motors rotate at a similar frequency in polymersomes and in solution.
In silico identification of novel PqsD inhibitors: promising molecules for quorum sensing interference in Pseudomonas aeruginosa
PqsD is an anthraniloyl-CoA anthraniloyltransferase involved in the synthesis of the secondary metabolites essential to the formation of Pseudomonas quinolone signal (PQS) inducer molecules.
About this collection
This special collection of MSDE, Guest Edited by Patrick Stayton (0000-0001-6939-6371) (University of Washington, USA) & José Rafael Bordin (0000-0002-8025-6529) (Federal University of Pelotas, Brazil) showcases the broad and diverse approaches to the cross-disciplinary field that is molecular bioengineering with a particular focus at the molecular level. We are particularly interested in receiving submissions at the interface of multiple disciplines and that showcase applied systems as well as novel design approaches.