Digital and analogical reality in proteomics investigation
Are protein functions continuous or discretized? Proteomics investigations are starting to address this non-trivial awesome question focusing upon determining the nature of biological molecular relationships.
Genotype–phenotype relationships in light of a modular protein interaction landscape
Better approaches tackling the modular nature of proteomes will have dramatic effects on the understanding of genotype–phenotype relationships, argue Matthias Gstaiger and Ruedi Aebersold.
The mitochondrial Italian Human Proteome Project initiative (mt-HPP)
mt-HPP: a new HUPO initiative on human mitochondrial proteins.
Application of proteomics technology in adipocyte biology
Obesity and its associated complications have reached epidemic proportions in Western-type societies.
Some remarks on predicting multi-label attributes in molecular biosystems
Many molecular biosystems and biomedical systems belong to the multi-label systems in which each of their constituent molecules possesses one or more than one function or feature, and hence needs one or more than one label to indicate its attribute(s).
Essential genes in Bacillus subtilis: a re-evaluation after ten years
An overview of essential genes in Bacillus subtilis with emphasis on changes in the list of essential genes since 2003.
Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome
Global identification of 501 in vivo protein methylations, combining hmSILAC with MS-proteomics, indicates predominance amongst complexes related to gene expression.
Proteomic analysis of temperature stress-responsive proteins in Arabidopsis thaliana rosette leaves
Proteomics of Arabidopsis leaves subjected to low or high temperature stress.
Crosstalk between salicylic acid and jasmonate in Arabidopsis investigated by an integrated proteomic and transcriptomic approach
Crosstalk between SA- and JA-mediated defence pathways is investigated for the first time by both proteomic and transcriptomic approaches.
Proteomic and ionomic profiling reveals significant alterations of protein expression and calcium homeostasis in cystic fibrosis cells
Altered protein expression profiles and Ca2+ dyshomeostasis in cystic fibrosis cells using integrated proteomic and ionomic analysis.
Integrative quantitation enables a comprehensive proteome comparison of two Mycoplasma pneumoniae genetic perturbations
Combination of six different protein quantitation strategies allowed confidently detection of protein abundance changes among distinct M. pneumoniae strains.
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy
LC-MSE proteomics revealed 27 differential tear proteins in naïve POAG vs. CTRL,13 of them were modulated in medically controlled POAG indicating a probable influence of therapy on the same molecular pattern.
Complementary biochemical approaches applied to the identification of plastidial calmodulin-binding proteins
Using a proteomic approach, we identified new plastidial CaM-binding candidates and validated a subset of them by overlay assays and fluorescence anisotropy.
Differential protein profiling of renal cell carcinoma urinary exosomes
The proteome of urinary exosomes from renal cell carcinoma patients is reproducibly different from healthy controls, as shown by a radar plot comparing the differential levels of selected proteins.
Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes
Comparison of fetal and adult human heart proteomes reflects the structural and biochemical differences between the two.
Red blood cell metabolism under prolonged anaerobic storage
MS-based untargeted metabolomics confirmed oxygen dependent modulation of red blood cell metabolism.
Unravelling the bull fertility proteome
A representative 2-DE map of a cryopreserved bull semen sample. Differentially expressed proteins are indicated in the map.
Alteration of proteomic profiles in PBMC isolated from patients with Fabry disease: preliminary findings
In Fabry patients, we found, by a proteomic approach, some down-regulated proteins (CALX, Rho GDI2, Rho GDI1, NCC27) and others upregulated (NSE, 1433T, 1433Z, Gal-1). These data could be related to pathophysiological aspects of disease.
Effect of IR laser on myoblasts: a proteomic study
IR laser treatment induces a general cytoskeleton reorganization and promotes the myoblast differentiation in vitro.
Urinary exosomes and diabetic nephropathy: a proteomic approach
Label-free LC-MS/MS assessment of differential proteome in urinary exosomes from ZDF diabetic rats, and immunoblotting validation, as exemplified by proteins in the inserts (MUP1, CD10, and PEPD).
Comparative proteome profiling of breast tumor cell lines by gel electrophoresis and mass spectrometry reveals an epithelial mesenchymal transition associated protein signature
In this work, we present a comparative proteome analysis of two breast cancer cell lines providing information about a set of proteins involved in the process of epithelial mesenchymal transition.
Detection of high molecular weight proteins by MALDI imaging mass spectrometry
Detection of high molecular weight proteins on thin tissue sections by imaging mass spectrometry is improved by the use of ferulic acid.
About this collection
Molecular BioSystems is delighted to present this collection of papers from the themed issue Proteomics 2013, guest edited by Andrea Urbani, President of the Italian Proteomics Association.