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Themed collection Immunotherapy

7 items
Editorial

Framing technology challenges associated with improving cancer immunotherapies

Thought leader Jim Heath introduces the Lab on a Chip Immunotherapy thematic collection.

Graphical abstract: Framing technology challenges associated with improving cancer immunotherapies
From the themed collection: Immunotherapy
Paper

MATE-Seq: microfluidic antigen-TCR engagement sequencing

Barcoded nanoparticles and an integrated DLD and droplet generator device are used to purify and sequence rare antigen-specific T cells.

Graphical abstract: MATE-Seq: microfluidic antigen-TCR engagement sequencing
From the themed collection: Immunotherapy
Paper

Microfluidic on-demand engineering of exosomes towards cancer immunotherapy

3D printing-based facile microfabrication of a microfluidic culture chip integrates harvesting, antigenic modification, and photo-release of surface engineered exosomes in one workflow, which enables rapid and real-time production of therapeutic exosomes for advancing cancer immunotherapy.

Graphical abstract: Microfluidic on-demand engineering of exosomes towards cancer immunotherapy
From the themed collection: Immunotherapy
Paper

Functional TCR T cell screening using single-cell droplet microfluidics

Droplet-based single cell platform allows functional screening and sorting of desirable TCR T cells to accelerate development of adoptive T cell therapies.

Graphical abstract: Functional TCR T cell screening using single-cell droplet microfluidics
From the themed collection: Immunotherapy
Paper

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

Our results demonstrate that multi-directional magnetic ratcheting offers a unique separation system for dealing with clinical samples that contain either rare cells or significantly small volumes.

Graphical abstract: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting
From the themed collection: Immunotherapy
Paper

A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions

A system for perfusing and interacting tumor fragments and immune cells and testing drug response with image analytics is reported.

Graphical abstract: A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions
From the themed collection: Immunotherapy
Paper

Cancer immunotherapy μ-environment LabChip: taking advantage of optoelectronic tweezers

An OET-based LabChip was developed to provide a stable and static culture μ-environment for cancer immunotherapy studies. The TiOPc-based OET facilitates the studies of cell–cell interaction resulting in apoptotic progress of cancer cells.

Graphical abstract: Cancer immunotherapy μ-environment LabChip: taking advantage of optoelectronic tweezers
From the themed collection: Immunotherapy
7 items

About this collection

A collection of recent reviews and research papers on the topic of immunotherapy and immunoengineering published in Lab on a Chip and curated by the Lab on a Chip Editorial Board. 

This topic area is currently the focus of a thematic collection in this field, led by Thought leader James R. Heath. More details about how to submit to the collection can be found at rsc.li/immunotherapy-blog.


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