Framing technology challenges associated with improving cancer immunotherapies
Thought leader Jim Heath introduces the Lab on a Chip Immunotherapy thematic collection.
MATE-Seq: microfluidic antigen-TCR engagement sequencing
Barcoded nanoparticles and an integrated DLD and droplet generator device are used to purify and sequence rare antigen-specific T cells.
Microfluidic on-demand engineering of exosomes towards cancer immunotherapy
3D printing-based facile microfabrication of a microfluidic culture chip integrates harvesting, antigenic modification, and photo-release of surface engineered exosomes in one workflow, which enables rapid and real-time production of therapeutic exosomes for advancing cancer immunotherapy.
Functional TCR T cell screening using single-cell droplet microfluidics
Droplet-based single cell platform allows functional screening and sorting of desirable TCR T cells to accelerate development of adoptive T cell therapies.
Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting
Our results demonstrate that multi-directional magnetic ratcheting offers a unique separation system for dealing with clinical samples that contain either rare cells or significantly small volumes.
A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions
A system for perfusing and interacting tumor fragments and immune cells and testing drug response with image analytics is reported.
Cancer immunotherapy μ-environment LabChip: taking advantage of optoelectronic tweezers
An OET-based LabChip was developed to provide a stable and static culture μ-environment for cancer immunotherapy studies. The TiOPc-based OET facilitates the studies of cell–cell interaction resulting in apoptotic progress of cancer cells.
About this collection
A collection of recent reviews and research papers on the topic of immunotherapy and immunoengineering published in Lab on a Chip and curated by the Lab on a Chip Editorial Board.
This topic area is currently the focus of a thematic collection in this field, led by Thought leader James R. Heath. More details about how to submit to the collection can be found at rsc.li/immunotherapy-blog.