Themed collection Microfluidics for hematology
Technologies for measuring red blood cell deformability
Advances in microfluidic technologies for measuring red blood cell deformability have surpassed traditional methods in terms of sensitivity, throughput, and ease of use. This review describes, compares, and covers applications of these technologies.
Point of care whole blood microfluidics for detecting and managing thrombotic and bleeding risks
Microfluidic techniques for the studying hemostatic processes have enabled research into disease, drug action, and biophysical phenomena. Refinement of these techniques from “chip in a lab” to “point-of-care” will enable improved clinical testing.
The role of liquid biopsies in prostate cancer management
This review describes recent advances in isolation and detection technology for circulating biomarkers. The clinical studies based on liquid biopsy results are summarized to provide a perspective on the role of such results in prostate cancer management.
Emerging point-of-care technologies for anemia detection
In this critical review, emerging non-invasive and minimally invasive point-of-care anemia detection technologies are discussed, highlighting future directions and the need for multiplexed approaches and integrated disease etiology identification.
Binding properties of flowing fibrin-targeted microbubbles evaluated with a thrombus-embedded microchannel
Assessing red blood cell deformability from microscopy images using deep learning
A microfluidic ratchet sorting device is used to separate RBCs based on deformability. Sorted cells are imaged using optical microscopy and are used to train and test a deep learning network to classify the cells based on deformability.
Immunomagnetic leukocyte differential in whole blood on an electronic microdevice
A cartridge-based, disposable magnetophoretic cytometer testing 3-part leukocyte differentials for point-of-care or self-testing applications.
Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood
We present a method that combines microfluidic systems and object-tracking computational technologies to evaluate the contributions of effective viscosity and wall friction to the overall resistance in blood from patients with sickle cell disease.
IL-2 secretion-based sorting of single T cells using high-throughput microfluidic on-cell cytokine capture
Secretion encoding workflow in which cells are co-encapsulated with anti-cytokine capture and detection probes in drops using a parallelized step emulsification device. Cells recovered from the emulsion are analysed and sorted by flow cytometry.
A 3D-printed transfusion platform reveals beneficial effects of normoglycemic erythrocyte storage solutions and a novel rejuvenating solution
A set of 3D-printed analytical devices were developed to investigate erythrocytes (ERYs) processed in conventional and modified storage solutions used in transfusion medicine.
An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs
This occlusive thrombosis-on-a-chip microfluidic device can be used to test antithrombotic drugs. The device uses an on-chip chaotic mixer to introduce EDTA and quench downstream coagulation, essential for reliable determination of occlusion time.
Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing
A point-of-care diagnostic technology and approach is presented to perform both anemia detection and hemoglobin variant identification in a single test using paper-based microchip electrophoresis.
Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion
Microfluidic Impedance Red Cell Assay (MIRCA) is integrated with capillary network-inspired micropillar arrays and electrical impedance sensing electrodes to enable standardized assessment of red blood cell-mediated microvascular occlusion.
Enhancement of inflection point focusing and rare-cell separations from untreated whole blood
Inertial lift force towards inflection points is enhanced by the combined effect of U-shape channel and co-flow, which enables unprecedented high-throughput cell separations from untreated whole blood.
Microfluidic assessment of red blood cell mediated microvascular occlusion
A gradient of microcapillary networks and microfluidic anastomoses enable standardized quantitative assessment of red blood cell mediated microvascular occlusion.
About this collection
A collection of recent reviews and research papers focusing on the topic of microfluidics for hematology published in Lab on a Chip. This topic area is currently the focus of a thematic collection in this field, led by Thought leaders Yoon-Kyoung Cho, Wilbur Lam and Abraham Lee.