Themed collection Host-Guest Chemistry

47 items
Feature Article

Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions

Helical building blocks can self-assemble into supramolecular helices via head-to-tail intermolecular interactions, wherein good propagation of helicity operates, exhibiting favourable homochiral elongation and functional helical channel structures.

Graphical abstract: Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions
From the themed collection: Host-Guest Chemistry
Feature Article

Macrocyclic host molecules with aromatic building blocks: the state of the art and progress

The diversity of aromatic building blocks, bridging groups, and their connection patterns determines the richness of macrocyclic host molecules (MHMs). The MHMs with new aromatic building blocks reported in the last ten years were summarized and discussed.

Graphical abstract: Macrocyclic host molecules with aromatic building blocks: the state of the art and progress
From the themed collection: Host-Guest Chemistry
Open Access Feature Article

Metal–organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics

We summarize recent progress in the enhanced delivery of biomacromolecular therapeutics for disease treatment using metal–organic frameworks (MOFs) as host materials.

Graphical abstract: Metal–organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics
From the themed collection: Host-Guest Chemistry
Feature Article

Covalently bridged pillararene-based oligomers: from construction to applications

This feature article reviews the structural design, synthetic methods, and multi-field applications of covalently bridged pillararene-based oligomers (CBPOs).

Graphical abstract: Covalently bridged pillararene-based oligomers: from construction to applications
From the themed collection: Host-Guest Chemistry
Accepted Manuscript - Communication

Synthesis of a Large-Cavity Carbazole Macrocycle for Size-Dependent Recognition

From the themed collection: Host-Guest Chemistry
Communication

A hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release

A hydrogel scaffold with a non-fouling but specific cancer cell-adhesive surface fabricated via host–guest interactions captures cancer cells and promotes growth and release of multicellular spheroids.

Graphical abstract: A hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release
From the themed collection: Host-Guest Chemistry
Communication

Silver nanoparticles modified by water-soluble leaning tower[6]arenes for sensing and catalysis

A hybrid nanoplatform was fabricated using a tower[6]arene sodium salt as a stabiliser on the surface of silver nanoparticles, showing good performance in catalysis and detection.

Graphical abstract: Silver nanoparticles modified by water-soluble leaning tower[6]arenes for sensing and catalysis
From the themed collection: Host-Guest Chemistry
Accepted Manuscript - Communication

Rotaxane-branched Radical Dendrimers with TEMPO Termini

From the themed collection: Host-Guest Chemistry
Communication

Tweezer-type binding cavity formed by the helical folding of a carbazole–pyridine oligomer

Helical folding of a carbazole–pyridine oligomer generates a tweezer-type binding cavity which allows for the intercalation of a naphthalenediimide guest.

Graphical abstract: Tweezer-type binding cavity formed by the helical folding of a carbazole–pyridine oligomer
From the themed collection: Host-Guest Chemistry
Communication

Pillararene-containing polymers with tunable fluorescence properties based on host–guest interactions

Linear polymers containing pillar[5]arenes as the pendant groups were designed and synthesized via a ring-opening metathesis polymerization. Such polymers could exhibit tunable fluorescence properties based on the host–guest interactions.

Graphical abstract: Pillararene-containing polymers with tunable fluorescence properties based on host–guest interactions
From the themed collection: Host-Guest Chemistry
Communication

Triple-stranded triptycene-based metallo-supramolecular helicate displaying efficient encapsulation of bulky guest molecules

A triple-stranded metallo-supramolecular helicate based on 2,7-disubstituted triptycene was easily constructed, and shows efficient encapsulation of quaternary ammonium guests.

Graphical abstract: Triple-stranded triptycene-based metallo-supramolecular helicate displaying efficient encapsulation of bulky guest molecules
From the themed collection: Host-Guest Chemistry
Communication

Multi-NSAID-based Zn(II) coordination complex-derived metallogelators/metallogels as plausible multi-drug self-delivery systems

Metallogelators/metallogels derived from a series of NSAID-based Zn(II) coordination complexes have been developed as plausible multi-drug self-delivery systems.

Graphical abstract: Multi-NSAID-based Zn(ii) coordination complex-derived metallogelators/metallogels as plausible multi-drug self-delivery systems
From the themed collection: Host-Guest Chemistry
Communication

Conductive and anti-freezing hydrogels constructed by pseudo-slide-ring networks

A pseudo-slide-ring network is introduced to enhance the hydrogel's mechanical performance, providing anti-freezing property and ionic conductivity.

Graphical abstract: Conductive and anti-freezing hydrogels constructed by pseudo-slide-ring networks
From the themed collection: Host-Guest Chemistry
Communication

Quickstart guide to model structures and interactions of artificial molecular muscles with efficient computational methods

Artificial molecular muscles are of interest in the nanosciences but their theoretical treatment is demanding. We present a standardized protocol on how to obtain reliable structures and free energies applying GFN quantum chemistry methods.

Graphical abstract: Quickstart guide to model structures and interactions of artificial molecular muscles with efficient computational methods
From the themed collection: Host-Guest Chemistry
Communication

Biophysical and in silico characterization of NrtA: a protein-based host for aqueous nitrate and nitrite recognition

A combination of isothermal titration calorimetry experiments and molecular dynamics simulations reveal how the NrtA protein recognizes nitrate versus nitrite in water.

Graphical abstract: Biophysical and in silico characterization of NrtA: a protein-based host for aqueous nitrate and nitrite recognition
From the themed collection: Host-Guest Chemistry
Communication

Structure and hydration of polyvinylpyrrolidone–hydrogen peroxide

Hydrogen peroxide–PVP used in tooth whitening involves a chain of hydrogen bonded H2O2 molecules that can be selectively substituted by water molecules.

Graphical abstract: Structure and hydration of polyvinylpyrrolidone–hydrogen peroxide
From the themed collection: Host-Guest Chemistry
Communication

Molecular recognition and photoprotection of riboflavin in water by a biomimetic host

A water-soluble tetralactam macrocycle is synthesized and characterized. This macrocycle is able to strongly bind riboflavin (Ka >107 M−1) in water and provides strong photoprotection of riboflavin upon UV irradiation.

Graphical abstract: Molecular recognition and photoprotection of riboflavin in water by a biomimetic host
From the themed collection: Host-Guest Chemistry
Communication

Host–guest complexation modulated aqueous polymerization-induced self-assembly for monodisperse hierarchical nanoflowers

This work presents the facile synthesis of monodisperse hierarchical nanoflowers by aqueous polymerization-induced self-assembly (PISA), modulated by host–guest interaction.

Graphical abstract: Host–guest complexation modulated aqueous polymerization-induced self-assembly for monodisperse hierarchical nanoflowers
From the themed collection: Host-Guest Chemistry
Communication

Supramolecular capture of highly polar amidosquaraine dye in water with nanomolar affinity and large turn-on fluorescence

A high-affinity supramolecular dye-capture system with “turn on” visible fluorescence is used to create a new assay for phospholipase-mediated liposome leakage.

Graphical abstract: Supramolecular capture of highly polar amidosquaraine dye in water with nanomolar affinity and large turn-on fluorescence
From the themed collection: Host-Guest Chemistry
Communication

Photoresponsive macrocycles for selective binding and release of sulfate

This work reports the synthesis of four photoresponsive macrocycles and their selective binding and release of SO42−via light irradiation.

Graphical abstract: Photoresponsive macrocycles for selective binding and release of sulfate
From the themed collection: Host-Guest Chemistry
Communication

Metal-dependent selective formation of calix[4]arene assemblies based on dynamic covalent chemistry

Two imine-based calix[4]arene assemblies were selectively formed by changing the conformation of the precursor by Na+ binding; the flattened and spread cone conformations gave a macrocyclic trimer and a capsular-shaped dimeric cage, respectively.

Graphical abstract: Metal-dependent selective formation of calix[4]arene assemblies based on dynamic covalent chemistry
From the themed collection: Host-Guest Chemistry
Communication

Threading of three rings on two stations: a convergent approach to [4]rotaxane

A novel approach to efficient and selective synthesis of [4]rotaxane with two stations was proposed to demonstrate the superiority of H-bonded azo-macrocycles in forging higher order rotaxanes.

Graphical abstract: Threading of three rings on two stations: a convergent approach to [4]rotaxane
From the themed collection: Host-Guest Chemistry
Communication

Adhesion behaviour of bulk supramolecular polymers via pillar[5]arene-based molecular recognition

Pillar[5]arene–acid-based supramolecular adhesives with tough adhesion performances on different substrates were obtained.

Graphical abstract: Adhesion behaviour of bulk supramolecular polymers via pillar[5]arene-based molecular recognition
From the themed collection: Host-Guest Chemistry
Communication

Bio-inspired AIE pillar[5]arene probe with multiple binding sites to discriminate alkanediamines

A pillar[5]arene functionalized with multiple binding sites can detect 1,8-diaminooctane, 1,10-diaminodecane, and 1,12-diaminododecane selectively and sensitively by using the AIE mechanism and the induced-fit mechanism.

Graphical abstract: Bio-inspired AIE pillar[5]arene probe with multiple binding sites to discriminate alkanediamines
From the themed collection: Host-Guest Chemistry
Communication

Chiral recognition coupled with chemometrics using boronate ensembles containing D–π–A cyanostilbenes

Chemometrics-coupled chiral recognition was conducted with boronate ensembles containing D–π–A cyanostilbenes to determine and predict enantiomer excess for guest amines.

Graphical abstract: Chiral recognition coupled with chemometrics using boronate ensembles containing D–π–A cyanostilbenes
From the themed collection: Host-Guest Chemistry
Communication

Dendronized polydiacetylenes via photo-polymerization of supramolecular assemblies showing thermally tunable chirality

Dendronized polydiacetylenes showing thermoresponsiveness were fabricated via photopolymerization of assembled ribbons from amphiphilic dendronized diacetylene in aqueous solutions, which simultaneously showed thermally switchable chiralities.

Graphical abstract: Dendronized polydiacetylenes via photo-polymerization of supramolecular assemblies showing thermally tunable chirality
From the themed collection: Host-Guest Chemistry
Communication

Multichannel dual protein sensing using amphiphilic supramolecular assemblies

A supramolecular dual protein sensing approach embedded with protein–ligand binding features and enzyme-cleavable moiety activating multichannel fluorescence signals via three different mechanisms.

Graphical abstract: Multichannel dual protein sensing using amphiphilic supramolecular assemblies
From the themed collection: Host-Guest Chemistry
Communication

Direct enhancement of intercomponent interactions in polyrotaxane and its pronounced effects on glass state properties

Intercomponent interactions in polyrotaxane glass influenced the mobility of the threading polymer confined in the glassy host framework, resulting in markedly different mechanical properties.

Graphical abstract: Direct enhancement of intercomponent interactions in polyrotaxane and its pronounced effects on glass state properties
From the themed collection: Host-Guest Chemistry
Communication

Steric control of sorting regimes in self-assembled cages

Self-sorting regimes are controlled by adjusting steric interactions in self-assembled coordination cages and equilibration followed by HPLC. Statistical or biased distributions can be obtained, including isolation of a single heteroleptic species.

Graphical abstract: Steric control of sorting regimes in self-assembled cages
From the themed collection: Chemical Communications HOT articles
Open Access Communication

Macrocyclic complexes based on [N⋯I⋯N]+ halogen bonds

Macrocyclic iodine(I) complexes with 5–10 Å cavity act as host molecules and encapsulate hexafluorophosphate anions in the gas phase confirmed by ion-mobility spectrometry and DFT calculations.

Graphical abstract: Macrocyclic complexes based on [N⋯I⋯N]+ halogen bonds
From the themed collection: Chemical Communications HOT articles
Communication

Polypseudorotaxanes constructed from pillar[5]arenes and polyamides by interfacial polymerization

Polypseudorotaxanes constructed from pillar[5]arene rings and polyamide chains were successfully synthesized by interfacial polymerization of polyamide in the presence of pillar[5]arene.

Graphical abstract: Polypseudorotaxanes constructed from pillar[5]arenes and polyamides by interfacial polymerization
From the themed collection: Host-Guest Chemistry
Communication

Visualization of lipophagy using a supramolecular FRET pair

Host–guest interactions between rationally designed fluorescent probes enable the visualization of lipophagy in live cells.

Graphical abstract: Visualization of lipophagy using a supramolecular FRET pair
From the themed collection: Host-Guest Chemistry
Communication

[2.2]Paracyclophane-bridged platinum(II) complexes for silver(I) recognition with emission enhancement

A [2.2]paracyclophane-bridged bimetallic alkynylplatinum(II) terpyridyl complex displays severe emission quenching due to the presence of intramolecular π–π interactions.

Graphical abstract: [2.2]Paracyclophane-bridged platinum(ii) complexes for silver(i) recognition with emission enhancement
From the themed collection: Host-Guest Chemistry
Communication

Self-sorting behavior in supramolecular fullerene polymerization directed by host–guest complexation between calix[5]arene and C60

Herein, we describe self-sorting supramolecular polymerization that uses chiral calix[5]arene hosts and a dumbbell-shaped fullerene guest.

Graphical abstract: Self-sorting behavior in supramolecular fullerene polymerization directed by host–guest complexation between calix[5]arene and C60
From the themed collection: Host-Guest Chemistry
Communication

Stable pseudo[3]rotaxanes with strong positive binding cooperativity based on shape-persistent aromatic oligoamide macrocycles

Six-residue aromatic oligoamide macrocycles bind bipyridinium guest G to form stable, compact pseudo[3]rotaxanes with strong positive cooperativity.

Graphical abstract: Stable pseudo[3]rotaxanes with strong positive binding cooperativity based on shape-persistent aromatic oligoamide macrocycles
From the themed collection: Host-Guest Chemistry
Communication

Turn on chemiluminescence-based probes for monitoring tyrosinase activity in conjunction with biological thiols

We report a chemiluminescent probe that permits the paired detection of tyrosinase (Tyr) and biological thiols. The Tyr-formed benzoquinone intermediate reacts with GSH and produces an enhanced chemiluminescence response.

Graphical abstract: Turn on chemiluminescence-based probes for monitoring tyrosinase activity in conjunction with biological thiols
From the themed collection: Host-Guest Chemistry
Communication

Hierarchical protein self-assembly into dynamically controlled 2D nanoarrays via host–guest chemistry

A dynamically reversible two-dimensional (2D) protein assembly system was designed based on host–guest interactions.

Graphical abstract: Hierarchical protein self-assembly into dynamically controlled 2D nanoarrays via host–guest chemistry
From the themed collection: Host-Guest Chemistry
Communication

Layered supramolecular network of cyclodextrin triplets with azobenzene-grafting polyoxometalate for dye degradation and partner-enhancement

A layered network supramolecular assembly is constructed by a tri-β-cyclodextrin-armed host and di-azobenzene-decorated polyoxometalate guest for degradation of selective dyes and partner-joined acceleration in water and dichloromethane in air.

Graphical abstract: Layered supramolecular network of cyclodextrin triplets with azobenzene-grafting polyoxometalate for dye degradation and partner-enhancement
From the themed collection: Host-Guest Chemistry
Communication

Room-temperature phosphorescence of a water-soluble supramolecular organic framework

A porous water-soluble supramolecular organic framework efficiently exhibiting phosphorescence was developed both in an aqueous phase and in film state at room-temperature.

Graphical abstract: Room-temperature phosphorescence of a water-soluble supramolecular organic framework
From the themed collection: Host-Guest Chemistry
Communication

Orientational self-sorting: formation of structurally defined Pd4L8 and Pd6L12 cages from low-symmetry dipyridyl ligands

Structurally defined Pd4L8 and Pd6L12 coordination cages are obtained from low-symmetry dipyridyl ligands.

Graphical abstract: Orientational self-sorting: formation of structurally defined Pd4L8 and Pd6L12 cages from low-symmetry dipyridyl ligands
From the themed collection: Host-Guest Chemistry
Communication

Biodegradable supramolecular micelles via host–guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones

Supramolecular polymer micelles are formed by host–guest interaction of cyclodextrin- and adamantane-terminated polypeptides and polycaprolactones. Enzyme degradation of the micelles leads to a controlled release of payload.

Graphical abstract: Biodegradable supramolecular micelles via host–guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones
From the themed collection: Host-Guest Chemistry
Communication

Recognition of hydrophilic molecules in deep cavitand hosts with water-mediated hydrogen bonds

A new supramolecular system was constructed based on water-mediated hydrogen bonding between a benzimidazole functionalized host, water and guest. Intriguingly, these hosts can recognize small hydrophilic guests in water through the synergistic action of water-mediated hydrogen bonding and hydrophobic effects.

Graphical abstract: Recognition of hydrophilic molecules in deep cavitand hosts with water-mediated hydrogen bonds
From the themed collection: Host-Guest Chemistry
Communication

Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness

A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host–guest inclusion complex, which could achieve the enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.

Graphical abstract: Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness
From the themed collection: Host-Guest Chemistry
Communication

Synergistic covalent-and-supramolecular polymers connected by [2]pseudorotaxane moieties

Synergistic covalent-and-supramolecular polymers connected by [2]pseudorotaxane moieties are designed and synthesized, whose unique topological structures lead to materials with mechanically adaptive properties.

Graphical abstract: Synergistic covalent-and-supramolecular polymers connected by [2]pseudorotaxane moieties
From the themed collection: Host-Guest Chemistry
Communication

Pyrrole-bridged quinones: π-electronic systems that modulate electronic structures by tautomerism and deprotonation

A new series of π-extended quinone derivatives containing a pyrrole bridge exhibited NH/OH-type tautomerization and anion binding along with deprotonation that induced near-infrared absorption and ion-pairing assemblies.

Graphical abstract: Pyrrole-bridged quinones: π-electronic systems that modulate electronic structures by tautomerism and deprotonation
From the themed collection: Host-Guest Chemistry
Communication

Pillararene-enriched linear conjugated polymer materials with thiazolo[5,4-d]thiazole linkages for photocatalysis

A conjugated polymer material integrated with pillararenes and codoped with heteroatoms was constructed for band-structure engineering and photocatalytic dye degradation.

Graphical abstract: Pillararene-enriched linear conjugated polymer materials with thiazolo[5,4-d]thiazole linkages for photocatalysis
From the themed collection: Host-Guest Chemistry
Communication

Measuring anion transport selectivity: a cautionary tale

pH-dependent liposomal assays are often used to determine anion selectivity in transmembrane anion transport experiments. In this communication, we discuss the validity and limitations of these assays, and provide guidelines for their use to avoid misleading results.

Graphical abstract: Measuring anion transport selectivity: a cautionary tale
From the themed collection: Host-Guest Chemistry
47 items

About this collection

Our vision is that this web collection will provide a showcase of current achievements while providing a springboard for future success in the field of host-guest chemistry. This collection, Guest Edited by Feihe Huang (Zhejiang University), Jonathan L. Sessler (The University of Texas at Austin), and Tomoki Ogoshi (Kyoto University), will cover not only host-guest complexes based on crown ethers, cyclodextrins, calixarenes, cucurbiturils, calixpyrroles, pillararenes, and other macrocyclic hosts, but also more complex supramolecular systems such as molecular switches, molecular machines, supramolecular polymers, supramolecular macromolecules and gels, macrocyclic amphiphiles, supra-amphiphiles, supra-monomers, supramolecular radicals, nonporous adaptive crystals, and other supramolecular materials based on host-guest chemistry. The collection will provide a spectrum of contributions that run the gamut from fundamental science all the way to real world applications involving areas as diverse as gene/drug delivery, smart/adaptive materials, devices, adsorption phenomena, separations, supramolecular chemotherapy, supramolecular cancer nanotheranostics, supramolecular analytical chemistry, information storage, coding and anti-counterfeitting, as well as supramolecular medicinal chemistry, to name a few of the many opportunities that are currently being perused. This collection intends to set a standard of excellence that will inspire current practitioners while attracting new researchers into the field.


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