SCHEDULED MAINTENANCE:
Highlight
Synergistic effects of combining phototherapeutics with traditional treatment modalities in oncology
Two together are more than two: the synergistic effects of combined phototherapeutics.
Overcoming the blood–brain barrier challenge: nanotechnology-enhanced photodynamic therapy for glioblastoma treatment
Recent clinical treatment modalities for GBM are systematically examined, the advances in nanotechnology-based novel photosensitizers for GBM treatment are summarized, and the drug delivery strategies utilized in PDT are discussed.
Engineering ultrasmall gold nanoclusters: tailored optical modulation for phototherapeutic and multimodal biomedical applications
Ultrasmall gold nanoclusters (Au NCs) enable precise synthesis, tunable optical properties, and versatile biomedical applications including multimodal imaging, biosensing, and phototherapy for advanced disease diagnosis and treatment.
Feature Article
The role of quantum dots in enhancing the therapeutic targeting of cancer stem cells
Cancer stem cells have emerged as an interesting field in oncology due to their metastatic and resistance potential to chemotherapy and radiation therapy, resulting in the resurfacing of cancer even after multiple treatment attempts.
Recent advances in fluorescent glycoconjugate probes for biosensing, bioimaging and targeted photodynamic therapy
This review summarizes recent advances in the development of functional glycoconjugates for biosensing, bioimaging and phototherapy.
Feature Article
Peptide self-assembly meets photodynamic therapy: from molecular design to antitumor applications
This review highlights the design of peptide-based photosensitive nanodrugs for photodynamic therapy, focusing on noncovalent interactions, structural design principles, and functional integration to improve therapeutic outcomes.
A PET-activated photosensitizer based on ROS-sensitive Trolox for tumor microenvironment-responsive imaging and therapy
A dormant photosensitizer, EtNBS-2C-Tro, was developed for tumor-selective photodynamic therapy through activation by ROS. EtNBS-2C-Tro facilitates NIR fluorescence imaging of endogenous ROS and exhibits a potent anticancer effect.
A bexarotene-attached Re(I) tricarbonyl complex for NADH oxidation and ROS-mediated cancer phototherapy
An axially substituted polypyridyl Re(CO)3 complex bearing bexarotene induced apoptosis selectively in cancer cells by activating caspase-3/7 pathways through ROS generation and NADH oxidation upon visible light treatment.
A near-infrared light-triggered covalent nanodrug for combined singlet oxygen therapy and photothermal therapy
This study presents a near-infrared light-triggered covalent nanodrug that integrates singlet oxygen therapy along with photothermal therapy.
Near-infrared chemiluminescent probes for monitoring leucine aminopeptidase activity
We report the first sequential near-infrared enzyme-specific chemiluminescent probe by minimizing steric hindrance at the recognition site to deliver robust in situ chemiluminescence.
About this collection
Photodynamic therapy (PDT) is an established clinical modality for treatment or localized types of conditions that has attracted significant attention due to its minimal invasiveness, high spatiotemporal selectivity, low systemic toxicity, and minimal risk of drug resistance. This special collection, guest edited by Professor Jong Seung Kim (Korea University, South Korea), Professor Gilles Gasser (PSL University, France), and Professor Qing-Zheng Yang (Beijing Normal University, China), showcases exciting developments in the field of PDT and covers a range of topics including the design of novel photosensitizers and diverse PDT applications in cancer therapy, antimicrobial treatments, and combination regimens with chemotherapy, immunotherapy, radiotherapy, and photothermal therapy.