Themed collection Chemosensors and Molecular Logic
Recent progress in the development of small-molecule double-locked logic gate fluorescence probes
Recent progress in the development of small-molecule double-locked logic gate fluorescence probes.
Recent applications of organic cages in sensing and separation processes in solution
Cages at work: structural tunability results in tailored properties, which makes these systems suitable for countless applications in sensing and separation processes, both in solution and the solid state.
Lanthanide-based logic: a venture for the future of molecular computing
This review critically examines the use of Ln3+-based molecular logic systems and discusses their potential integration into future molecular photonic-electronic hybrid systems.
Excited-state intramolecular proton transfer (ESIPT)-based fluorescent probes for biomarker detection: design, mechanism, and application
Biomarkers are essential in biology, physiology, and pharmacology; thus, their detection is of extensive importance.
Converting pH probes into “turn-on” fluorescent receptors for anions
The feature article outlines the design concept for the construction of “turn-on” fluorescent receptors for anions using fluorescent pH probes. Applications of this concept for the construction of fluorescent receptors for anions are described.
Recent advances in fluorescence chemosensors for ammonia sensing in the solution and vapor phases
In this review article, we have highlighted the recent advancements in the design of fluorescence chemosensors for sensing ammonia both in the solution and vapor phases.
A dual encapsulation strategy to generate anion-responsive luminescent lanthanide hydrogels
We report a new method to generate ion-responsive luminescent hydrogels, involving encapsulation of a luminescent lanthanide probe within crosslinked amphiphilic polymer particles and subsequent entrapment within a hydrogel.
Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6
Despite the apparent copious fluorescent probes targeting mitochondria, the development of low cytotoxic probes is still needed. We have newly developed a novel NIR mitochondrial probe that exhibits low toxicity.
Amyloid peptide hydrogels via formation of coordination polymers with Ag+ by its core peptide equipped with a C-cysteine
Hydrogelation of a KLVFF peptide equipped with a C-terminal cysteine residue was realized at a concentration of 0.05 wt% in the presence of Ag+.
NMN sensor cocktail: selective sensing of nicotinamide mononucleotide over citric acid
A sensor cocktail, composed of two fluorescent dyes, NBD-B2 and Styryl-51F, selectively senses nicotinamide mononucleotide (NMN) over citric acid through their ratiometric fluorescence changes.
Supramolecular self-assembled polymeric nanospheres based on hydrazino naphthalimide functionalised pillararene for long chain aldehyde detection
A novel fluorescent sensor composed of bis-hydrazino naphthalimide decorated with a pillararene motif demonstrated highly selective fluorescent sensing of nonanal and octanal via self-assembled supramolecular polymeric nanoparticles.
Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems
Unlabelled bacterial lectin LecA causes enhancement of terbium(III)-centred emission from glycoconjugate, with sensing driven by the lectin's selective carbohydrate-binding.
Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT
A simple yet powerful D–A type-based NIR-II fluorophore (MTF) with mitochondria targeting was constructed.
Spontaneous preparation of a fluorescent ratiometric chemosensor for metal ions using off-the-shelf materials
A self-assembled ratiometric chemosensor, which was prepared by simply mixing an off-the-shelf catechol fluorophore and an off-the-shelf phenylboronic acid derivative, has achieved pattern recognition of metal ions in river water.
Formation of lanthanide luminescent di-metallic helicates in solution using a bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligand
Bis-tridentate (1,2,3-triazol-4-yl)picolinamide (tzpa) was used to form Tb(III) double- and triple-stranded di-metallic helicates in solution, where changes in the absorption and the Tb(III) emission were used to monitor the formation of these supramolecular systems.
Accurate photoactivation monitoring via the construction of an intramolecular synergistic counteracting mechanism of FRET and IFE
We propose an intramolecular synergistic counteracting strategy of fluorescence resonance energy transfer and the inner filter effect for accurate photoactivation monitoring, to eliminate the influence of the biological microenvironment.
Selective detection of peroxynitrite using an isatin receptor and a naphthalimide fluorophore
A turn-on isatin receptor based naphthalimide fluorescent probe encapsulated in PEG was used to rapidly detect peroxynitrite in cells.
Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging
A heavy-atom-free photosensitizer (CI) showed strong singlet oxygen generation, efficient photodynamic therapy and fluorescence bioimaging under two-photon excitation.
A white light emitting reconfigurable pyrazoline-naphthalimide logic gate with magnesium, sodium and proton inputs
A 3-pyrazolinyl-naphthalimide is demonstrated as a wavelength-reconfigurable dual-output logic gate that emits orange light on binding Na+ and white light on binding Mg2+.
Transmembrane transport of fluoride studied by time-resolved emission spectroscopy
The encapsulation of a lanthanide-based probe in liposomes allows monitoring of fluoride transmembrane transport using time-resolved emission spectroscopy, which makes it possible study fluorescent transporters.
Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg2+
New Eu(III)-based indicators enable luminescence-based detection of polyphosphate-bound Mg2+ species, a highly dynamic pool of biomolecule-bound magnesium in cells.
Phototransduction in a supramolecular cascade: a mimic for essential features of the vision process
A photoactive supramolecular five-component system mimics essential features of the natural vision process.
SERS microsensors for pH measurements in the lumen and ECM of stem cell derived human airway organoids
SERS microsensors (SERS-MS) are polymer microparticles coated in gold nanoparticles and functionalised with mercaptobenzoic acid. SERS-MS were incorporated into human airway organoids to measured pH optically.
Molecularly imprinted and cladded polymers for constructing a portable plasmonic immunoassay for peptides in biofluids
An inexpensive, fast and portable plasmonic immuno-sandwich assay (PISA) based on two molecularly imprinted and cladded polymers (cMIPs) was developed for high-specificity and ultra-sensitive quantitation of C-peptide in urine.
γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging
Combining γ-glutamyl transpeptidase and pH dual-responsive sites, an “and” logic gate-based NIR fluorescent probe Si-NH2-Glu was developed for orthotopic breast tumor imaging.
Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe
Hydrogen sulfide (H2S) in the endoplasmic reticulum of living systems could be imaged using probe ER-Nap-NBD.
A NIR fluorescent probe for the detection of renal damage based on overrepresentation of alanine aminopeptidase enzyme
Here, we describe the design of a molecular probe (NB-ALA) based on the Nile Blue fluorophore, which can detect alanine aminopeptidase enzyme (a kidney damage biomarker) in urine by simple fluorometric measurements.
Supramolecular chiral sensing by supramolecular helical polymers
The helicity of the supramolecular porphyrin polymers was determined by the chirality of solvent molecules, which permitted the polymer chains to be used in chiral sensing.
Double click macrocyclization with Sondheimer diyne of aza-dipyrrins for B–Free bioorthogonal imaging
Sequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin.
An entropy-driven DNA nanomachine for microRNA detection using a personal glucose meter
A reliable and portable TDR-PGM nanomachine was facilely constructed for highly sensitive detection of miRNA by integrating the entropy-driven TDR amplifier and the catalytic invertase biocatalyst.
Si-rhodamine fluorescent probe for monitoring of hypochlorous acid in the brains of mice afflicted with neuroinflammation
The fluorescent probe SiR-FH realized real-time monitoring of HClO in the brains of mice with LPS-induced neuroinflammation.
Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury
An endoplasmic reticulum targeting NIR fluorescent probe (ERBM) was developed for real-time monitoring of carboxylesterase 1 (CES1) and exhibited excellent ER location in living cell imaging.
Quinoxaline-fused octaphyrin(22.214.171.124.126.96.36.199). A rudimentary chemosensor
A quinoxaline-fused octaphyrin(188.8.131.52.184.108.40.206) was synthesized by the FeCl3-induced oxidative coupling of an α-free quinoxaline-fused tetrapyrrole.
A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging
A near-infrared fluorescent probe ENBO-ML210 was developed. In vitro and in vivo imaging results showed that it could target and visualize GPX4 in H1299 cells, exhibiting the potential for diagnosis of non-small lung cancer.
A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells
A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells.
Three-state fluorescence hydrochromism of a fluorophore–spacer–receptor system with variations in relative humidity
Atmospheric water adsorbed hygroscopically with changes in relative humidity triggers changes in fluorescence emission wavelength for a charged fluorophore leading to three-state fluorescence hydrochromic switching in the solid state.
TCF-based fluorescent probe for monitoring superoxide anion produced in bacteria under chloramphenicol- and heat-induced stress
We report on a superoxide anion (O2˙−) responsive fluorescent probe called TCF-OTf.
An NO-responsive probe for detecting acute inflammation using NIR-II fluorescence/optoacoustic imaging
An activatable probe for detecting acute inflammation has been developed. Nitrosation turns electron-donating methylamine into electron-withdrawing methyl-N-nitroso with turn-on NIR-II fluorescence and optoacoustic signals for imaging.
New cell-membrane-anchored near-infrared fluorescent probes for viscosity monitoring
We developed new cell-membrane-anchored fluorescent probes for viscosity detection. Probe MYN-BS has been successfully applied in the monitoring of cell membrane viscosity during temperature change and cell foaming.
SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy
A new bioconjugate based on glioblastoma multiforme (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is disclosed.
A fluorescent probe strategy for the detection and discrimination of hydrogen peroxide and peroxynitrite in cells
We report a fluorescent probe strategy that provides the potential to detect and discriminate hydrogen peroxide and peroxynitrite in cells.
A pH-activated fluorescent probe via transformation of azo and hydrazone forms for lysosomal pH imaging
A pyridone-based hydrazone probe Sth-NH is established for monitoring the lower lysosomal pH of cancer cells via a turn-on fluorescence mode.
An endoplasmic reticulum targeting green fluorescent protein chromophore-based probe for the detection of viscosity
The occurrence of endoplasmic reticulum (ER) stress is the main cause of a variety of biological processes that are closely related to numerous diseases.
Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage
NAN0-N3 and NAN6-N3 could monitor DNA damage induced by the overexpression of H2S.
A red-NIR fluorescent probe for rapid and visual detection of acrolein
A red-NIR turn-on fluorescent probe has been developed for rapid, sensitive and colorimetric detection of toxic acrolein.
Two boron atoms versus one: high-performance deep-blue multi-resonance thermally activated delayed fluorescence emitters
Two new deep-blue narrowband multi-resonant emitters, 1B-DTACrs and 2B-DTACrs, one of which shows TADF, based on boron, nitrogen, and oxygen doped nanographenes are reported.
About this collection
This themed collection, guest edited by Tony James (University of Bath), Juyoung Yoon (Ewha Womans University), Engin Akkaya (Dalian University of Technology) and Thorfinnur Gunnlaugsson (Trinity College Dublin), on “Chemosensors and Molecular Logic” aims to highlight the current state of the art and future directions of these two interlinked areas. These areas of research were pioneered by Anthony W. Czarnik (21-11-1957) a founding light for “chemosensors” which are compounds of abiotic origin that complex to an analyte reversibly to generate a fluorescence signal and AP DeSilva (29-4-1952) who serendipitously (under a coconut tree) visualized “Molecular Logic” a branch of chemical science that highlights the connection between information technology (engineering and biological) and chemistry.