Review Article
Bringing enzymes to the proximity party
Targeted enzymes can drive cell type-selective reactions that are not yet possible with other therapeutic approaches.
Review Article
Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction
This review surveys molecular glue-induced ternary complexes in the PDB and provides an overview of computational methods that can be utilized to predict them.
Paper
Bind&Bite: covalently stabilized heterodimeric coiled-coil peptides for the site-selective, cysteine-free chemical modification of proteins
A pair of heterodimeric coiled-coil peptides was modified to enable covalent stabilization of the dimer without using enzymes or cysteine. Fusion of the peptides to a protein and a chemical moiety, respectively, facilitates site-selective protein modification.
Paper
A model-informed method to retrieve intrinsic from apparent cooperativity and project cellular target occupancy for ternary complex-forming compounds
Estimating intrinsic from apparent cooperativities to calculate concentrations of ternary complexes in biochemical and cellular assays.
Paper
Straightforward model construction and analysis of multicomponent biomolecular systems in equilibrium
A framework for equilibrium models, such as molecular glues and other contemporary biomolecular multicomponent systems, is presented that automatically generates custom mass-balance models based on the reversible reactions of each system.
Paper
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design
The Petasis borono-Mannich reaction was employed for an entry towards three-branched cereblon ligands. The high-affinity ligands were used to assemble molecular glues and proteolysis targeting chimeras (PROTACs) targeting BRD4 for degradation.
About this collection
This themed collection, guest edited by Michelle Arkin (University of California San Francisco, USA), Luc Brunsveld (TU Eindhoven, Netherlands), and Eric Fischer (Dana-Farber Cancer Institute and Harvard Medical School, USA), encompasses the wide scope of molecular glues. Topics include protein degradation glues, protein binders and stabilizers, bi-functional molecules for protein degradation and beyond with a particular interest on molecular recognition.