Themed collection 2022 RSC Chemical Biology Emerging Investigators
RSC Chemical Biology Emerging Investigators Collection and Outstanding Paper Award
This collection showcases research carried out by internationally recognised, up-and-coming scientists in the early stage of their independent careers who are making outstanding contributions to their respective fields.
Contributors to the RSC Chemical Biology Emerging Investigators Collection 2022
This article profiles the early career researchers whose work features in the RSC Chemical Biology Emerging Investigators Collection 2022.
Fluorescent metabolic labeling-based quick antibiotic susceptibility test for anaerobic bacteria
Via a fluorescent D-amino acid (FDAA) labeling-based antibiotic susceptibility test method, the minimum inhibitory concentrations of anaerobic bacteria were accurately determined in ∼5 h.
A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
A dual-responsive doxorubicin–indoximod conjugate was developed, which allows for sequential on-demand release of doxorubicin and indoximod for programmed chemoimmunotherapy.
A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules
Combination bioorthogonal chemical reporter strategy and photo-reaction enables imaging of newly-synthesized glycans, lipids and proteins with spatiotemporal resolution.
The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
Difficult peptide sequences can be synthesized in high quality by combining the polar CSY aspartate protecting group and selective microwave irradiation.
Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines
We report the first structures of bacterial HAQs bound to their target DHODH and provide insights into mechanism of inhibition.
One-step asparaginyl endopeptidase (OaAEP1)-based protein immobilization for single-molecule force spectroscopy
Enzymatic protein ligation has become the most powerful and widely used method for high-precision atomic force microscopy-based single-molecule force spectroscopy (AFM-SMFS) study of protein mechanics.
Improved ClickTags enable live-cell barcoding for highly multiplexed single cell sequencing
A versatile and highly reproducible approach for live cell sample multiplexing is achieved by DNA barcoding via “click chemistry” in single-cell RNA-seq.
Proteomic characterization of phagocytic primary human monocyte-derived macrophages
We report a first-in-class dataset of proteins detectable and synthesized in primary human monocyte-derived macrophages. Macrophages stimulated with interferon-gamma are more phagocytic and synthesize more proteins than steady-state macrophages.