Issue 4, 2022

The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides

Abstract

This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides.

Graphical abstract: The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides

Supplementary files

Article information

Article type
Communication
Submitted
24 Dec 2021
Accepted
18 Feb 2022
First published
18 Feb 2022
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2022,3, 426-430

The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides

T. L. Pham, J. Zilke, C. C. Müller and F. Thomas, RSC Chem. Biol., 2022, 3, 426 DOI: 10.1039/D1CB00252J

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