Themed collection Biomaterials for Imaging and Sensing

Guest editors Jesse Jokerst and Kanyi Pu introduce the Biomaterials Science themed collection on Biomaterials for Imaging and Sensing.

In this minireview, synergistic agents for focused ultrasound tumor treatment are reviewed in four therapy mechanisms: sonodynamic plus chemotherapy, microbubble-aided therapy, localized drug delivery, and photoacoustic image-guided therapy.

Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has been promising for the construction of molecular probes for in vivo imaging.

Gold nanoparticles are promising OCT and PAI contrast agents for ophthalmic imaging because of their high light scattering/absorption from SPR.

Polymers can facilitate delivery of nitric oxide, improving stability and control of release for effective treatment of common skin disorders.

Peptide-based supramolecular hydrogels have unique merits in bioimaging applications.

This review discusses key outcome measures for TERM constructs and various imaging techniques that can be used to assess them.

Strand amplifying HCR and CHA are adaptable with signalers for novel and clinically translatable nucleic acid sensors and imaging agents.

This review mainly summarized the recent results that used bright polymer dots (Pdots) for the detection of different analytes such as reactive oxygen species (ROS), metal ions, pH values, and a variety of biomolecules.

This review mainly introduces the phosphorescent probes applied in vitro and in vivo bioimaging.

This review discusses various recent strategies based on different targeting ligands to improve the tumor-specific targeting of nanoprobes toward precision imaging diagnosis.

A bioprobe with aggregation-induced emission characteristics is developed, which can visualize and photodynamically ablate Gram-negative bacteria in a selective manner.

Obesity is associated with systemic inflammation due to macrophage accumulation in adipose tissue (AT).

Tb doped core/shell/shell nanophosphor exhibits robust X-ray luminescence and potential in radiodynamic therapy.

Coloring dyes reveal potential as optical imaging contrast agents for cancer detection. Tattoo and Design created by artist Adam Sky.

We developed ATTO655 dye-conjugated cetuximab for fast and real-time fluorescence imaging of EGFR-positive lung cancers.

PSA was conjugated onto IONP by first covalently linking Neu onto a 10 nm IONP core and then attaching PSA to neu via biotin–avidin interaction. When applied in vivo, IONP-Neu-PSA-Cy5.5 produced persistent near-IR signal specifically for monitoring tumor apoptosis.

The direct linkage of two camptothecin moieties to a metal chelator creates a self-assembling prodrug capable of associating in aqueous solution into theranostic supramolecular polymers.

The two novel anilino quinazoline-based EGFR-TKIs have promising anti-tumor activity and limited hepatotoxicity, representing excellent candidates for combating the NSCLC.

A dozen commercial NIR-II dyes are screened for simple formulation and one is applied for in vivo optical imaging in mice.

An iron oxide nanoparticle conjugated with a cocaine analogue exhibits small size and long-term stability with the ability to target dopamine transporter-expressing neurons and provides excellent contrast enhancement under MRI, demonstrating great potential for neuroimaging.

Peptide-tuned TTA-UC luminescence is reported by the formation of UC chromophore-assembled tetrahedral nanorods. Intense UC emission from the upconversion donor to acceptor in nanorods can be observed in non-deoxygenated water.

Both the specific aggregation of PFT-SH in cancer cells and its ROS producing ability led to its use in the targeted killing of cancer cells through efficient photodynamic therapy.