Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity
Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has been promising for the construction of molecular probes for in vivo imaging.
Hybridizing clinical translatability with enzyme-free DNA signal amplifiers: recent advances in nucleic acid detection and imaging
Strand amplifying HCR and CHA are adaptable with signalers for novel and clinically translatable nucleic acid sensors and imaging agents.
Recent advances in improving tumor-targeted delivery of imaging nanoprobes
This review discusses various recent strategies based on different targeting ligands to improve the tumor-specific targeting of nanoprobes toward precision imaging diagnosis.
Recent advances in semiconducting polymer dots as optical probes for biosensing
Development of phosphorescent probes for in vitro and in vivo bioimaging
Quenched cetuximab conjugate for fast fluorescence imaging of EGFR-positive lung cancers
Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window
A dozen commercial NIR-II dyes are screened for simple formulation and one is applied for in vivo optical imaging in mice.
Cocaine analogue conjugated magnetic nanoparticles for labeling and imaging dopaminergic neurons
An iron oxide nanoparticle conjugated with a cocaine analogue exhibits small size and long-term stability with the ability to target dopamine transporter-expressing neurons and provides excellent contrast enhancement under MRI, demonstrating great potential for neuroimaging.
A highly selective iron oxide-based imaging nanoparticle for long-term monitoring of drug-induced tumor cell apoptosis
PSA was conjugated onto IONP by first covalently linking Neu onto a 10 nm IONP core and then attaching PSA to neu via biotin–avidin interaction. When applied in vivo, IONP-Neu-PSA-Cy5.5 produced persistent near-IR signal specifically for monitoring tumor apoptosis.
Theranostic supramolecular polymers formed by the self-assembly of a metal-chelating prodrug
The direct linkage of two camptothecin moieties to a metal chelator creates a self-assembling prodrug capable of associating in aqueous solution into theranostic supramolecular polymers.
Peptide assembly assisted triplet–triplet annihilation photon upconversion in non-deoxygenated water
Peptide-tuned TTA-UC luminescence is reported by the formation of UC chromophore-assembled tetrahedral nanorods. Intense UC emission from the upconversion donor to acceptor in nanorods can be observed in non-deoxygenated water.
In situ self-assembly of conjugated polyelectrolytes for cancer targeted imaging and photodynamic therapy
Both the specific aggregation of PFT-SH in cancer cells and its ROS producing ability led to its use in the targeted killing of cancer cells through efficient photodynamic therapy.
Novel anilino quinazoline-based EGFR tyrosine kinase inhibitors for treatment of non-small cell lung cancer
The two novel anilino quinazoline-based EGFR-TKIs have promising anti-tumor activity and limited hepatotoxicity, representing excellent candidates for combating the NSCLC.
About this collection
A collection of original research and reviews focussing on Biomaterials for Imaging and Sensing. The goal of this collection is to highlight the most exciting advances in responsive materials, as applied to real-time analysis of analytes relevant to life sciences including proteins, electrolytes and cells. Both in vivo and in vitro measurements were welcome. Here, we define biomaterials broadly including any number of soft or hard materials including plasmonic materials, polymeric systems, self-condensing approaches, biomimicry etc.
Guest Edited by Jesse Jokerst (UC San Diego, USA) and Kanyi Pu (Nanyang Technological University, China).