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In situ self-assembly of conjugated polyelectrolytes for cancer targeted imaging and photodynamic therapy

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Abstract

The construction of intelligent self-assembly systems with cancer targeting photodynamic therapy abilities is highly required for increasing the precise therapeutic efficiency in clinical treatment. Herein, a cationic water soluble conjugated polymer (PFT-SH) functionalized with thiol groups was designed and synthesized via a palladium-catalyzed Suzuki coupling reaction. Firstly, PFT-SH can enter cells and form loose aggregations by hydrophobic and π–π stacking interactions. Secondly, a high level of H2O2 in cancer cells oxidizes sulfhydryl groups to disulfide bonds and then forms more and larger aggregations. Finally, PFT-SH showed remarkable ROS producing ability under white light irradiation with 78% quantum yields (ΦΔ). Due to this unique self-aggregation property, PFT-SH was successfully used to achieve in situ self-assembly specifically inside cancer cells for targeted imaging. Both the specific aggregation of PFT-SH in cancer cells and its ROS producing ability led to its use in the targeted killing of cancer cells through efficient photodynamic therapy.

Graphical abstract: In situ self-assembly of conjugated polyelectrolytes for cancer targeted imaging and photodynamic therapy

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Supplementary files

Article information


Submitted
27 Nov 2019
Accepted
05 Feb 2020
First published
07 Feb 2020

Biomater. Sci., 2020, Advance Article
Article type
Paper

In situ self-assembly of conjugated polyelectrolytes for cancer targeted imaging and photodynamic therapy

S. S. Khatoon, Y. Chen, H. Zhao, F. Lv, L. Liu and S. Wang, Biomater. Sci., 2020, Advance Article , DOI: 10.1039/C9BM01912J

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