Themed collection Antibacterial Biomaterials

Jianfeng Cai and Runhui Liu introduce the Biomaterials Science themed issue on antibacterial biomaterials.

Pathogenic microbial biofilms that readily form on implantable medical devices or human tissues have posed a great threat to worldwide healthcare.

Amphiphilic antimicrobial polymers show promising potential as polymer therapeutics to fight drug resistant bacteria and biofilms.

Recent developments of photothermal bactericidal surfaces based on immobilized photothermal agents to kill bacteria through hyperthermia effects are reviewed.

In this review, we introduce anti-bacterial nanosystems for cancer therapy in the aspects of spontaneous and triggered anti-bacterial action.

This review highlights the different mechanisms of current nano-antibiotic systems for combatting serious antibiotic resistance of bacteria.

This review thus provides a feasible guide to developing nanoengineered antibacterial polymers by presenting both broad and in-depth bench research, and it offers suggestions for their potential in biomedical applications.

Bacterial growth over biomaterials can be controlled by adjusting the size, shape and composition of their surface topography.

Helix is a two-edged sword for AMPs, and conformational modulation of AMPs can control the balance between antimicrobial activity and toxicity.

This review focus on the recent advances in surface modification strategies of biomedical catheters used to prevent CRIs.

We report the design and investigation of a class of short dimeric antimicrobial lipo-α/sulfono-γ-AA hybrid peptides by mimicking the mechanism of action of host-defense peptides.

The dental resins incorporated with a penicillin V (PV)-based polymer–antibiotic conjugate (PAC) demonstrate significant antibacterial properties.

Electrostatic nanomicelles remain stable and biocompatible under physiological conditions, but readily burst and spill out cationic antimicrobial peptide to kill bacteria at infection sites.

A novel type of polypeptoids containing both sulfonium and oligo(ethylene glycol) moieties were prepared, which show rapid and potent antibacterial activity as well as good hemocompatibility.

Conductive and antimicrobial macroporous hydrogels have shown promising applications in promoting soft tissue regeneration.

An α/β chimeric polypeptide molecular brush shows excellent performance in eradicating established biofilms, persister cells, and clinically isolated multi-drug resistant Gram-positive bacteria.

Synergistic killing of Gram negative bacteria by polymers that disrupt bacterial membranes and translocate and precipitate cytosolic proteins and nucleic acids.

A novel sprayable PEG-PDA hydrogel adhesive can instantly gel to close wounds, providing synergistic antibacterial activities through ROS and hyperthermia.

An injectable hydrogel wound dressing based on an oxidized dextran and ε-poly-L-lysine network has multiple biological activities.

We establish an “on-demand” nanoplatform based on acid-degradable scaffolds by conjugating glycomimetic-based galactose ligands to target a key lectin on P. aeruginosa and guanidine moieties.

A new class of biopolymer coating based on amyloid-like protein aggregates is reported to combine both antifouling and antibacterial activity.

A well-organized hierarchical structure and appropriate alkyl chain length facilitate the synergistic anti-biofilm effect.

Bioadhesives are of great interest for tissue/wound closure to reduce surgical time, minimize treatment invasiveness, and prevent body fluid leakage.

This material of Cu doped MoS₂ can produce reactive oxygen species and photothermal under 660 nm light, thus achieving a rapid bacterial effect. Which is a kind of good photothermal and photodynamic material.

An amino-containing tannic acid derivative was self-polymerized to form colorless and uniform coatings on various substrate surfaces, and the resultant coatings can be further utilized to construct bioactive, antifouling and antibacterial surfaces.

An enzyme-responsive nanoplatform was fabricated on Ti substrates to treat implant-associated bacterial infection and accelerate tissue growth in vivo.