Themed collection Biomaterials Science Most Popular 2021

NIR light-based theranostics become very crucial in the field of cancer nanomedicine. This review summarizes the recent advances of NIR light activatable multi-functional materials for cancer phototheranostics.

The basics of nanomedicine-based ferroptosis are summarized. The applications and future research directions of nanomedicine for ferroptosis-based anticancer therapy are presented.

Biomaterial -based therapy in burn wound care and the roles and advantages of hydrogels.

Cartilage-like hydrogels based on materials like gelatin, chondroitin sulfate, hyaluronic acid and polyethylene glycol are reviewed and contrasted, revealing existing limitations and challenges on biomimetic hydrogels for cartilage regeneration.

The hydrogel dressings with various functions for diabetic wound treatment.

Restricted entry into the cells stands as an ultimate challenge for nanotherapeutics to exhibit their efficacy. Cell penetrating peptides can act as a crucial assistant for overcoming this challenge.

Nanodiamonds were demonstrated to have great effects on inhibiting biofilm formation as well as disrupting the preformed biofilm in several selected orally and systemically important organisms.

Cur–CSNPs mediated PDT suppress TNBC through the synergistic immunotherapeutic effects by suppressing the expression of HIF-1α to reprogram the pro-tumor TAM2 into the anti-tumor TAM1.

The prepared polydeoxyribonucleotide (PDRN)-loaded alginate/chitosan-based hydrogel as a “nanocomposite smart material” combines the advantages of gene vectors and hydrogels and promotes the wound healing process.

Gene activated scaffolds incorporating star-shaped polypeptide-pDNA nanomedicines accelerate bone tissue regeneration in vivo.

A multicomponent nanodrug based on polymeric micelles has been fabricated and examined for its potential in combined photodynamic therapy, chemotherapy and hypoxia-activated therapy of cancer.

Repair of osteochondral defects is still a challenge, especially the regeneration of hyaline cartilage.

Injectable and biodegradable DNA gel nanoparticles with a controllable charge and size as a photothermal therapeutic agent improve the permeability of drugs, reduce drug resistance, and improve the survival rate of mice.

We developed GRAS nanofibers for the delivery of viable bacteria into the gut. Model bacterium were encapsulated in alginate-based nanofibers via electrospinning and a bacteria loading of 2.74 × 10⁵ CFU g⁻¹ of mat was achieved.

High-purity milk exosomes were engineered with surface PEGylation and siRNA encapsulation for enhanced oral drug delivery.

An injectable hydrogel system fabricated with functionalised chondroitin sulfate and a hyperbranched multi-functional PEG polymer was developed as a stem cell delivery system for cartilage tissue engineering.

A protein-based injectable hydrogel was prepared in a convenient way and applied for biomedical applications as hemostatic and wound dressing materials.

We introduce a scaffold combining 3D structural alignment and electrical conductivity for skeletal muscle tissue engineering. We show that aligned and conductive scaffolds support myoblast viability, 3D alignment, and early myotube formation.

3D-printed biphasic core/shell hydrogel scaffolds with hybrid bioactive nanoparticles reinforcing core phase possessed controlled swelling, mechanical stiffness and dual-ranged pore size. They provided prominent osteoconductivity, biocompatibility and in-vivo osteogenicity.

Glycosylation can be a promising tool for engineering protein-based biomaterials specifically regarding adhesion.

Cell containing hydrogels represent a key strategy in tissue engineering. Complex mechanical analyses show that the stiffness significantly drops for high concentrations of cells and microgel-bead fillers in non-fibrous alginate-based hydrogels.

The biopolymer bacterial nanocellulose presents attractive mechanical and anti-adherent properties for innovative hernia repair solutions.

3D cellularized structures revealing dermal-like properties have been successfully printed using bioinks based on the sulfated polysaccharide ulvan from Australian green seaweed.

Molecular mobility of polyrotaxane-based biointerfaces altered the cellular morphology and gene expression of pro-inflammatory cytokines in the presence of lipopolysaccharide.

This work provides microenvironmental design parameters to optimize iPSC-cardiomyocyte tissues formed on tunable synthetic matrices that mimic myocardial ECM.