Themed collection Advanced Separation

13 items
Minireview

Metal–organic frameworks as advanced materials for sample preparation of bioactive peptides

This minireview summarizes the recent advances in MOF-based affinity materials for the sample preparation of bioactive peptides.

Graphical abstract: Metal–organic frameworks as advanced materials for sample preparation of bioactive peptides
From the themed collection: Advanced Separation
Critical Review

Advances in epitope molecularly imprinted polymers for protein detection: a review

Epitope molecularly imprinted polymers (EMIPs) are novel imprinted materials using short characteristic peptides as templates rather than entire proteins.

Graphical abstract: Advances in epitope molecularly imprinted polymers for protein detection: a review
From the themed collection: Advanced Separation
Critical Review

Recent technical progress in sample preparation and liquid-phase separation-mass spectrometry for proteomic analysis of mass-limited samples

Recent development of sample preparation methods with nanoliter processing volumes, ultrasensitive LC-MS/MS and CZE-MS/MS systems for proteomics of mass-limited samples.

Graphical abstract: Recent technical progress in sample preparation and liquid-phase separation-mass spectrometry for proteomic analysis of mass-limited samples
From the themed collection: Advanced Separation
Critical Review

Methods for isolation of messenger RNA from biological samples

mRNA molecules are critical components in living organisms. Isolation of highly pure mRNA is the first step in many biological researches. This review focuses on the methodologies and protocols for isolating mRNA populations.

Graphical abstract: Methods for isolation of messenger RNA from biological samples
From the themed collection: Advanced Separation
Critical Review

Chiral porous organic frameworks and their application in enantioseparation

The application of CMOFs and CCOFs as CSPs for chromatographic chiral separation.

Graphical abstract: Chiral porous organic frameworks and their application in enantioseparation
From the themed collection: Advanced Separation
Paper

Fluorescent detection of target proteins via a molecularly imprinted hydrogel

A molecularly imprinted hydrogel with a PEG-fluorescent monomer was used for the selective detection of a target protein.

Graphical abstract: Fluorescent detection of target proteins via a molecularly imprinted hydrogel
From the themed collection: Advanced Separation
Paper

Simultaneous metabolomics and proteomics analysis of plasma-derived extracellular vesicles

A tandem extraction strategy was established to obtain metabolites and proteins from the same batch of extracellular vesicles (EVs) simultaneously, enabling the multi-omics differential analysis of exosomes and microvesicles from human plasma.

Graphical abstract: Simultaneous metabolomics and proteomics analysis of plasma-derived extracellular vesicles
From the themed collection: Advanced Separation
Paper

A new urinary exosome enrichment method by a combination of ultrafiltration and TiO2 nanoparticles

The workflow of separation and enrichment of exosomes by ultrafiltration–TiO2. We proposed a new strategy for facile exosome isolation from human urine by utilizing the ultrafiltration technique and TiO2, which can significantly reduce urine volumes, increase exposure of the material to exosomes in urine and obtain high purity exosomes.

Graphical abstract: A new urinary exosome enrichment method by a combination of ultrafiltration and TiO2 nanoparticles
From the themed collection: Advanced Separation
Paper

Development of the C12Im-Cl-assisted method for rapid sample preparation in proteomic application

C12Im-Cl could work as a protein solubilizer compatible with trypsin digestion and reduced the protein digestion time to one hour.

Graphical abstract: Development of the C12Im-Cl-assisted method for rapid sample preparation in proteomic application
From the themed collection: Advanced Separation
Paper

Quantitative proteomics of epigenetic histone modifications in MCF-7 cells under estradiol stimulation

SILAC-based quantitative proteomics strategy deciphers the mechanism of epigenetic regulation for breast cancer cell under estradiol stimulation.

Graphical abstract: Quantitative proteomics of epigenetic histone modifications in MCF-7 cells under estradiol stimulation
From the themed collection: Advanced Separation
Paper

Highly selective enrichment and direct determination of imazethapyr residues from milk using magnetic solid-phase extraction based on restricted-access molecularly imprinted polymers

RAM-MIPs was prepared as MSPE material for selective extraction of trace IMs and possessed satisfactory protein exclusion properties.

Graphical abstract: Highly selective enrichment and direct determination of imazethapyr residues from milk using magnetic solid-phase extraction based on restricted-access molecularly imprinted polymers
From the themed collection: Advanced Separation
Paper

ZnO/SiO2 core/shell nanowires for capturing CpG rich single-stranded DNAs

Modification of the surface of ZnO nanowires through atomic layer deposition (ALD) for the fabrication of a ZnO/SiO2 (core/shell) nanowire microfluidic device for capturing CpG-rich single-stranded DNAs (ssDNAs).

Graphical abstract: ZnO/SiO2 core/shell nanowires for capturing CpG rich single-stranded DNAs
From the themed collection: Advanced Separation
Paper

Probing the methotrexate–protein interactions by proteomics and thermostability assay for drug resistance study

Quantitative proteomics combined with thermostability assay provide a novel strategy for the study of mechanisms on drug action and resistance.

Graphical abstract: Probing the methotrexate–protein interactions by proteomics and thermostability assay for drug resistance study
From the themed collection: Advanced Separation
13 items

About this collection

A collection of papers and reviews on the topics of advanced materials and substances for separation, microseparation, multidimensional separation, 3D printing for separation, electrophoretic cytometry, and advanced separation techniques for challenging applications (such as food safety and -omics studies).

This collection is Guest Edited by Analytical Methods Associate Editor, Zhen Liu (Nanjing University, China), Wenwan Zhong (University of California, Riverside, USA) and Takuya Kubo (Kyoto University, Japan). 

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