Pharmaceutical Analysis
Guest Editor Melissa Hanna-Brown introduces the Pharmaceutical Analysis themed issue.
Detection of native chondroitin sulfate impurities in heparin sodium with a colorimetric micro-plate based assay
Naked-eye detection of DS in heparin sodium API.
Study on the interaction behavior of catalase with cephalosporins by chemiluminescence with flow injection analysis
Catalase (CAT) enhanced the chemiluminescence (CL) intensity from luminol; cephalosporins quenched the CL intensity of luminol–CAT; the interaction of CAT with cephalosporins was studied by CL method with flow injection analysis.
Optimisation of an HPLC method for the simultaneous determination of pyrantel pamoate, praziquantel, fenbendazole, oxfendazole and butylhydroxyanisole using a phenyl stationary phase
A novel HPLC method for the simultaneous determination of active anthelmintic components has been developed and validated.
Determination of anticonvulsants in human plasma using SPME in a heated interface coupled online to liquid chromatography (SPME-LC)
A simple and sensitive method using solid phase microextraction (SPME) and liquid chromatography (LC) with heated online desorption (SPME-LC) was developed and validated to analyze anticonvulsants (AEDs) in human plasma samples.
Development and validation of a rapid HPLC method for the determination of ascorbic acid, phenylephrine, paracetamol and caffeine using a monolithic column
Fast and simple liquid chromatographic method for determination of ascorbic acid, phenylephrine, paracetamol and caffeine. Salicylic acid was used as internal standard. The analytes were successfully separated in less than 5 min by isocratic elution using monolithic column.
A simple UV-photolysis digestion method for the determination of fluoride in fluorine-containing drugs by ion-selective electrode and spectrophotometry techniques
A UV-photolysis digestion method for the routine determination of fluoride in a variety of drug samples containing single to multiple fluoride constituents.
An assay of DNA by resonance light scattering technique and its application in screening anticancer drugs
A novel assay for the detection of DNA and a novel method for screening DNA-targeted anticancer drugs is developed based on resonance light scattering.
A new and simple PLS calibration method for NIR spectroscopy . API determination in intact solid formulations
A new method for API determination in intact formulations based on calculation of process spectra is proposed and applied to production tablets. No reference method is needed.
Chromatographic determination of active compounds in topical formulations
Two novel simple methods for the determination of active substances in topical formulations were described. The first method—HPLC with UV detection—was used to determine trimecaine, nonoxinol-9, using amitriptyline as the internal standard, and the second method—GC with flame ionisation detection—deals with the determination of terpinen-4-ol using geraniol as the internal standard.
Enantioanalysis of ketoprofen based on its interaction with C60 fullerene and its derivatives
C60 fullerenes were used for the enantioselective assay of ketoprofen.
Application of a glassy carbon electrode modified with functionalized multi-walled carbon nanotubes as a sensor device for simultaneous determination of acetaminophen and tyramine
The simultaneous determination of Ac and Tyr was investigated using functionalized multi-wall carbon nanotubes (fMWCNT) modified glassy carbon electrodes as a simple, sensitive and selective electrochemical sensor.
A sensitive chemiluminescence determination of isoproterenol in pharmaceutical and human serum using luminol –diperiodatoargentate(III) system
A novel, sensitive and simple chemiluminescence method is developed for the determination of isoproterenol in human serum and pharmaceutical preparations.
Automated analysis of oseltamivir and oseltamivir carboxylate in environmental waters by online in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry
An automated method is developed for determination of oseltamivir and oseltamivir carboxylate in environmental waters by online in-tube SPME LC-MS/MS.
Development and validation of a new and rapid HPLC for determination of lyophilized teicoplanin
A sensitive, precise, accurate and specific HPLC method for the analysis of teicoplanin is developed and validated.
Determination of volatile residual solvents in pharmaceutical products by static and dynamic headspace liquid-phase microextraction combined with gas chromatography-flame ionization detection
Comparision of two solvent microextraction methods (headspace single-drop microextraction and dynamic headspace liquid-phase microextraction) for the determination of thirteen volatile residual solvents in pharmaceutical products is presented.
Compression effect on sustained-release and water absorption properties of cellulose tablets studied by heterospectral two-dimensional (2D) correlation analysis
The effect of compression on tablet dissolution was probed by NIR spectroscopy and X-ray diffraction to reveal the underlying phenomena of tablet compression and deformation.
Automated analysis of non-steroidal anti-inflammatory drugs in human plasma and water samples by in-tube solid-phase microextraction coupled to liquid chromatography-mass spectrometry based on a poly(4-vinylpyridine-co-ethylene dimethacrylate) monolith
A poly(VP-co-EDMA) monolith was prepared as a rapid and sensitive analysis method for three NSAIDs in human plasma and water.
NMR reaction monitoring during the development of an active pharmaceutical ingredient
The power of using NMR in combination with Mid-IR data to improve process understanding, during the development of imagabalin hydrochloride synthesis, is shown.
About this collection
These papers are part of a themed issue on Pharmaceutical Analysis, Guest Edited by Melissa Hanna-Brown (Pfizer/University of Warwick), Tony Killard (University of the West of England) and Craig Lunte (Kansas University).