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Themed collection Pharmaceutical Analysis

19 items
Editorial

Pharmaceutical Analysis

Guest Editor Melissa Hanna-Brown introduces the Pharmaceutical Analysis themed issue.

Graphical abstract: Pharmaceutical Analysis
From the themed collection: Pharmaceutical Analysis
Communication

Detection of native chondroitin sulfate impurities in heparin sodium with a colorimetric micro-plate based assay

Naked-eye detection of DS in heparin sodium API.

Graphical abstract: Detection of native chondroitin sulfate impurities in heparin sodium with a colorimetric micro-plate based assay
From the themed collection: Pharmaceutical Analysis
Communication

Study on the interaction behavior of catalase with cephalosporins by chemiluminescence with flow injection analysis

Catalase (CAT) enhanced the chemiluminescence (CL) intensity from luminol; cephalosporins quenched the CL intensity of luminol–CAT; the interaction of CAT with cephalosporins was studied by CL method with flow injection analysis.

Graphical abstract: Study on the interaction behavior of catalase with cephalosporins by chemiluminescence with flow injection analysis
From the themed collection: Pharmaceutical Analysis
Paper

Optimisation of an HPLC method for the simultaneous determination of pyrantel pamoate, praziquantel, fenbendazole, oxfendazole and butylhydroxyanisole using a phenyl stationary phase

A novel HPLC method for the simultaneous determination of active anthelmintic components has been developed and validated.

Graphical abstract: Optimisation of an HPLC method for the simultaneous determination of pyrantel pamoate, praziquantel, fenbendazole, oxfendazole and butylhydroxyanisole using a phenyl stationary phase
From the themed collection: Pharmaceutical Analysis
Paper

Determination of anticonvulsants in human plasma using SPME in a heated interface coupled online to liquid chromatography (SPME-LC)

A simple and sensitive method using solid phase microextraction (SPME) and liquid chromatography (LC) with heated online desorption (SPME-LC) was developed and validated to analyze anticonvulsants (AEDs) in human plasma samples.

Graphical abstract: Determination of anticonvulsants in human plasma using SPME in a heated interface coupled online to liquid chromatography (SPME-LC)
From the themed collection: Pharmaceutical Analysis
Paper

Development and validation of a rapid HPLC method for the determination of ascorbic acid, phenylephrine, paracetamol and caffeine using a monolithic column

Fast and simple liquid chromatographic method for determination of ascorbic acid, phenylephrine, paracetamol and caffeine. Salicylic acid was used as internal standard. The analytes were successfully separated in less than 5 min by isocratic elution using monolithic column.

Graphical abstract: Development and validation of a rapid HPLC method for the determination of ascorbic acid, phenylephrine, paracetamol and caffeine using a monolithic column
From the themed collection: Pharmaceutical Analysis
Paper

A simple UV-photolysis digestion method for the determination of fluoride in fluorine-containing drugs by ion-selective electrode and spectrophotometry techniques

A UV-photolysis digestion method for the routine determination of fluoride in a variety of drug samples containing single to multiple fluoride constituents.

Graphical abstract: A simple UV-photolysis digestion method for the determination of fluoride in fluorine-containing drugs by ion-selective electrode and spectrophotometry techniques
From the themed collection: Pharmaceutical Analysis
Paper

An assay of DNA by resonance light scattering technique and its application in screening anticancer drugs

A novel assay for the detection of DNA and a novel method for screening DNA-targeted anticancer drugs is developed based on resonance light scattering.

Graphical abstract: An assay of DNA by resonance light scattering technique and its application in screening anticancer drugs
From the themed collection: Pharmaceutical Analysis
Paper

A new and simple PLS calibration method for NIR spectroscopy. API determination in intact solid formulations

A new method for API determination in intact formulations based on calculation of process spectra is proposed and applied to production tablets. No reference method is needed.

Graphical abstract: A new and simple PLS calibration method for NIR spectroscopy. API determination in intact solid formulations
From the themed collection: Pharmaceutical Analysis
Paper

Chromatographic determination of active compounds in topical formulations

Two novel simple methods for the determination of active substances in topical formulations were described. The first method—HPLC with UV detection—was used to determine trimecaine, nonoxinol-9, using amitriptyline as the internal standard, and the second method—GC with flame ionisation detection—deals with the determination of terpinen-4-ol using geraniol as the internal standard.

Graphical abstract: Chromatographic determination of active compounds in topical formulations
From the themed collection: Pharmaceutical Analysis
Paper

Enantioanalysis of ketoprofen based on its interaction with C60 fullerene and its derivatives

C60 fullerenes were used for the enantioselective assay of ketoprofen.

Graphical abstract: Enantioanalysis of ketoprofen based on its interaction with C60 fullerene and its derivatives
From the themed collection: Pharmaceutical Analysis
Paper

Application of a glassy carbon electrode modified with functionalized multi-walled carbon nanotubes as a sensor device for simultaneous determination of acetaminophen and tyramine

The simultaneous determination of Ac and Tyr was investigated using functionalized multi-wall carbon nanotubes (fMWCNT) modified glassy carbon electrodes as a simple, sensitive and selective electrochemical sensor.

Graphical abstract: Application of a glassy carbon electrode modified with functionalized multi-walled carbon nanotubes as a sensor device for simultaneous determination of acetaminophen and tyramine
From the themed collection: Pharmaceutical Analysis
Paper

A sensitive chemiluminescence determination of isoproterenol in pharmaceutical and human serum using luminol–diperiodatoargentate(III) system

A novel, sensitive and simple chemiluminescence method is developed for the determination of isoproterenol in human serum and pharmaceutical preparations.

Graphical abstract: A sensitive chemiluminescence determination of isoproterenol in pharmaceutical and human serum using luminol–diperiodatoargentate(iii) system
From the themed collection: Pharmaceutical Analysis
Paper

Automated analysis of oseltamivir and oseltamivir carboxylate in environmental waters by online in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry

An automated method is developed for determination of oseltamivir and oseltamivir carboxylate in environmental waters by online in-tube SPME LC-MS/MS.

Graphical abstract: Automated analysis of oseltamivir and oseltamivir carboxylate in environmental waters by online in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry
From the themed collection: Pharmaceutical Analysis
Paper

Development and validation of a new and rapid HPLC for determination of lyophilized teicoplanin

A sensitive, precise, accurate and specific HPLC method for the analysis of teicoplanin is developed and validated.

Graphical abstract: Development and validation of a new and rapid HPLC for determination of lyophilized teicoplanin
From the themed collection: Pharmaceutical Analysis
Paper

Determination of volatile residual solvents in pharmaceutical products by static and dynamic headspace liquid-phase microextraction combined with gas chromatography-flame ionization detection

Comparision of two solvent microextraction methods (headspace single-drop microextraction and dynamic headspace liquid-phase microextraction) for the determination of thirteen volatile residual solvents in pharmaceutical products is presented.

Graphical abstract: Determination of volatile residual solvents in pharmaceutical products by static and dynamic headspace liquid-phase microextraction combined with gas chromatography-flame ionization detection
From the themed collection: Pharmaceutical Analysis
Paper

Compression effect on sustained-release and water absorption properties of cellulose tablets studied by heterospectral two-dimensional (2D) correlation analysis

The effect of compression on tablet dissolution was probed by NIR spectroscopy and X-ray diffraction to reveal the underlying phenomena of tablet compression and deformation.

Graphical abstract: Compression effect on sustained-release and water absorption properties of cellulose tablets studied by heterospectral two-dimensional (2D) correlation analysis
From the themed collection: Pharmaceutical Analysis
Paper

Automated analysis of non-steroidal anti-inflammatory drugs in human plasma and water samples by in-tube solid-phase microextraction coupled to liquid chromatography-mass spectrometry based on a poly(4-vinylpyridine-co-ethylene dimethacrylate) monolith

A poly(VP-co-EDMA) monolith was prepared as a rapid and sensitive analysis method for three NSAIDs in human plasma and water.

Graphical abstract: Automated analysis of non-steroidal anti-inflammatory drugs in human plasma and water samples by in-tube solid-phase microextraction coupled to liquid chromatography-mass spectrometry based on a poly(4-vinylpyridine-co-ethylene dimethacrylate) monolith
From the themed collection: Pharmaceutical Analysis
Paper

NMR reaction monitoring during the development of an active pharmaceutical ingredient

The power of using NMR in combination with Mid-IR data to improve process understanding, during the development of imagabalin hydrochloride synthesis, is shown.

Graphical abstract: NMR reaction monitoring during the development of an active pharmaceutical ingredient
From the themed collection: Pharmaceutical Analysis
19 items

About this collection

These papers are part of a themed issue on Pharmaceutical Analysis, Guest Edited by Melissa Hanna-Brown (Pfizer/University of Warwick), Tony Killard (University of the West of England) and Craig Lunte (Kansas University).

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