Themed collection Analyst Review Articles 2022

Biomass materials have abundant natural resources, renewability and good biochemical compatibility, so biomass-based fluorescent materials prepared from biomass materials have gradually become a research hotspot.

Rolling circle amplification (RCA) is a simple and isothermal DNA amplification technique that is used to generate thousands of repeating DNA sequences using circular templates under the catalysis of DNA polymerase.

An overview of recent progress in electrochemiluminescence microscopy analysis of single cells classified according to different ECL routes, namely the oxidative-reduction, low oxidation potential, catalytic and direct oxidation routes.

Microfluidic platforms with 3D tumour spheroid culture provide platforms to study the multi-cellular interactions and external stimuli in the complex tumour microenvironment.

We review the recent progress in semiconductor-based SERS. We mainly discuss the enhancement mechanism, SERS-active materials for semiconductors, and potential strategies to improve the SERS performance.

This tutorial review presents the most important practical considerations for sample preparation, instrument set-up, image acquisition and data analysis to obtain reproducible SRS measurements.

We describe the scientific, engineering work over the first ten years of PharmaChk, the first quantitative, portable instrument for medicine quality screening, to illustrate what it takes for academic labs to translate observations into interventions.

Upconversion nanoparticles have gained more attention due to their unique photon conversion capability from an incident wavelength to a more suitable emission wavelength at a designated site, thus improving their scope in analytical and biomedical sciences.

In recent years, with the rapid development of electrochemiluminescence (ECL) sensors, more luminophores have been designed to achieve high-throughput and reliable analysis.

A tutorial on non-destructive and high spatial resolution ATR-FTIR spectroscopic imaging approaches for the analysis of cultural heritage objects.

Near-infrared small molecular fluorescence probes for targeted diagnosis of Alzheimer's disease.

This review highlights the current state of knowledge in the development of GC × GC-MS for the analysis of clinical metabolites. Selected applications are described as well as our perspectives on current challenges and potential future directions.

The possibilities of virus identification, including SARS-CoV-2, by MALDI-TOF mass spectrometry are discussed in this review.

Mass spectrometry-based metabolomics approaches to characterize the complex intracellular chemistry of organoids are reviewed, expanding the field of organoid research.

Recent progress in biointerface research has highlighted the role of antifouling functionalizable coatings in the development of advanced biosensors for point-of-care applications dealing with real-world complex samples.

MiRNAs are related to cancer drug resistance through various mechanisms. The advanced detection methods for the miRNAs are reviewed.

This review focuses on the instrumental development and potential applications of Tandem-Trapped Ion Mobility Spectrometry/Mass Spectrometry (tTIMS/MS) for protein structure elucidation.

This review focuses on the recent advances in the fundamentals of single-cell droplet microfluidics and its applications in biomedicine, providing insights into design and establishment of single-cell microsystems and their further performance.

Review on laboratory-based methods and biosensors and wearable sensors for detecting wound infection by aerobic and anaerobic bacteria.

Depletion-free molecular ink deposition with accurate volume control allows for the fabrication of droplet-based bioanalytical assays.

Small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems are summarized.