AFM, SECM and QCM as useful analytical tools in the characterization of enzyme-based bioanalytical platforms
A review of the use of AFM, SECM and QCM as analytical tools in the characterization of enzyme-based bioanalytical platforms is presented.
Homogeneous assays using
This review is the first entirely dedicated to aptamer- and aptazyme-based homogeneous assays carried out in a solution phase.
mass spectrometry for simultaneous acquisition of elemental and molecular information
Recent developments in plasma-based mass spectrometric instrumentation for integrated (elemental and molecular) chemical speciation studies are presented.
Fourier transform mass spectrometry for metabolome analysis
We evaluate the improvements provided for metabolomics by different types of FT/MS instruments, together with the ability of these platforms to cover the various analytical requirements of metabolomics.
Intracellular magnesium detection: imaging a brighter future
The state of the art and future developments in intracellular magnesium detection by fluorescent sensors and live imaging are discussed.
single-walled carbon nanotubes for direct and selective electrochemical detection of DNA
Hybridization of the complementary DNA sequence breaks interactions between the redox probe and the DNA probe, which speeds-up electron transfer.
Study of the capillary electrophoresis profile of intact α-1-acid glycoprotein isoforms as a
biomarker of atherothrombosis
Statistical analysis shows that the CE profile of intact AGP purified by immunoaffinity chromatography from plasma is a potential biomarker of atherothrombosis.
New nanostructured electrochemical biosensors based on three-dimensional
Electrochemical response and morphological characterization by SEM and AFM of a new nanostructured biosensor based on three-dimensional (3-mercaptopropyl)-trimethoxysilane network.
Opto-electrochemical nanosensor array for remote DNA detection
A high-density array of opto-electrochemical nanosensors is presented for remote DNA detection through a nanostructured optical fiber bundle.
DNA hybridization induced selective encapsulation of small dye molecules in dendrimer based microcapsules
A novel approach for selectively encapsulating Cy5 dye molecules via DNA hybridization in cationic phosphorus dendrimers (G4+)/polystyrenesulfonate (PSS) microcapsules has been developed.
In situ identification and imaging of bacterial
polymer nanogranules by infrared nanospectroscopy
The AFM-IR technique using an IR laser and AFM is a tool suited to chemical analysis at the nanometric scale. The identification and imaging of 50–400 nm size polyhydroxybutyrate (PHB) granules inside a single Rhodobacter capsulatus bacterium illustrate the exciting potentiality of this new photothermal near-field technique.
detection of hydrogen peroxide by triggered activation of horseradish peroxidase
Reconstitution of hemin di(N,N′-acetylhydrazide) with apo horseradish peroxidase and hydrogen peroxide for the ultra-sensitive detection of H2O2 and glucose oxidase.
Viable route for switching of an engineered
silica surface using Cu2+ ions at sub-ppm levels
The novel monolayer architecture allows specific reversible switching between two states using Cu2+ ions as input and the absorbance intensity as output. Switching is straightforward and the optical read-out fast.
Disposable immunosensor for
cortisol using functionalized magnetic particles
A novel electrochemical immunosensor using screen-printed carbon electrodes and functionalized magnetic particles was developed for the determination of cortisol.
cell geometry and number of replicas in the reproducibility of whole cell FTIR analysis
This paper shows for the first time the effects of cell shape and dimensions on the spectra quality and variability.
Non-linear multivariate curve resolution analysis of voltammetric pH
Non-linearity correction in voltammetric pH titrations using shape constraints for modelling the shifts in peak potentials.
Screen-printed microsystems for the ultrasensitive
electrochemical detection of alkaline phosphatase
The fabrication of a low cost, easy to manufacture microsystem and its application to achieve ultrasensitive electrochemical detection of alkaline phosphatase is herein described.
Polymers with embedded chemical indicators as an artificial olfactory mucosa
Olfactory mucosa inspired a novel approach to chemical sensors. The concept is demonstrated with two polymer layers embedded with a chemical indicator. Multivariate analysis illustrates the synergy of polymer and indicator properties.
Selective electrochemical discrimination between
dopamine and phenethylamine-derived psychotropic drugs using electrodes modified with an acyclic receptor containing two terminal 3-alkoxy-5-nitroindazole rings
Ion insertion solid state electrochemistry is used to determine the amount of phenethylamine, dopamine, homoveratrylamine, mescaline, (±)-amphetamine, (±)-p-methoxyamphetamine, and (±)-methamphetamine in aqueous media with high selectivity.
About this collection
Analyst has collected together some of the latest exciting research published in the journal from researchers working in France, Italy and Spain. Read the highlighted articles in this web themed issue, which has been guest edited by José Pingarrón (Complutense University of Madrid, Spain) and Serge Cosnier (Université Joseph Fourier, France).