Issue 28, 2021

A fast and direct iodide-catalyzed oxidative 2-selenylation of tryptophan

Abstract

A metal-free 2-selenylation of tryptophan derivatives is reported, where the use of iodide as the catalyst and oxone as the oxidant is key to obtain high yields. Various functional groups within the di-seleny and the indole ring are tolerated, and no racemization is generally observed.

Graphical abstract: A fast and direct iodide-catalyzed oxidative 2-selenylation of tryptophan

Supplementary files

Article information

Article type
Communication
Submitted
05 Feb 2021
Accepted
01 Mar 2021
First published
02 Mar 2021

Chem. Commun., 2021,57, 3504-3507

A fast and direct iodide-catalyzed oxidative 2-selenylation of tryptophan

Y. Gao, S. Liu, L. Cheng and L. Liu, Chem. Commun., 2021, 57, 3504 DOI: 10.1039/D1CC00700A

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