Issue 28, 2021
From the journal:

Chemical Communications

A dual-rotator fluorescent probe for analyzing the viscosity of mitochondria and blood†

Manlin Fu,a   Yue Sun,a   Kenry,b   Miao Zhang,a   Haihua Zhou,c   Wei Shen,*c   Yi Hu ORCID logo *d  and  Qing Zhu ORCID logo *a  

* Corresponding authors

a College of Biotechnology and Bioengineering & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
E-mail: zhuq@zjut.edu.cn

b Department of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA

c Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, China
E-mail: shenweiri@163.com

d CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and University of Chinese Academy of Sciences (UCAS), Chinese Academy of Sciences (CAS), Beijing 100049, China
E-mail: huyi@ihep.ac.cn

Abstract

A novel mitochondria-targeting molecular rotator FD was designed to visualize changes in viscosity under hypoxic conditions in vitro and in vivo. Importantly, FD can be used to detect changes in the blood viscosity of liver cancer and liver cirrhosis patients, and also rehabilitation of liver disease.

Graphical abstract: A dual-rotator fluorescent probe for analyzing the viscosity of mitochondria and blood

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Supplementary files

Article information

DOI
https://doi.org/10.1039/D1CC00519G
Article type
Communication
Submitted
29 Jan 2021
Accepted
03 Mar 2021
First published
04 Mar 2021

Chem. Commun., 2021,57, 3508-3511

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A dual-rotator fluorescent probe for analyzing the viscosity of mitochondria and blood

M. Fu, Y. Sun, Kenry, M. Zhang, H. Zhou, W. Shen, Y. Hu and Q. Zhu, Chem. Commun., 2021, 57, 3508 DOI: 10.1039/D1CC00519G

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