Issue 72, 2018

Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands

Abstract

The Gd(III)-complexes of three novel HP-DO3A-like ligands have been investigated to assess the relationship between relaxometry and intramolecular catalysis of the proton exchange. The structures of these ligands differ from the parent HP-DO3A because the methyl group of the hydroxy-propyl arm has been replaced by –Ph–OH, –Ph–NH2 and –Ph–COOH, respectively. The phenol, amine and carboxylate functionalities display an intramolecular H-bonding with the coordinated hydroxyl moiety that affects either the pK values of the involved functionalities and the rate of the proton exchange process.

Graphical abstract: Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands

Supplementary files

Article information

Article type
Communication
Submitted
01 Jul 2018
Accepted
10 Aug 2018
First published
22 Aug 2018

Chem. Commun., 2018,54, 10056-10059

Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(III)-complexes of HP-DO3A-like ligands

I. M. Carnovale, M. L. Lolli, S. C. Serra, A. F. Mingo, R. Napolitano, V. Boi, N. Guidolin, L. Lattuada, F. Tedoldi, Z. Baranyai and S. Aime, Chem. Commun., 2018, 54, 10056 DOI: 10.1039/C8CC05284K

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