Issue 1, 2017
From the journal:

Chemical Communications

A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights†‡

D. Montagner,ab   B. Fresch,cd   K. Browne,a   V. Gandin*e  and  A. Erxleben*a  

* Corresponding authors

a School of Chemistry, National University of Ireland Galway, Ireland
E-mail: andrea.erxleben@nuigalway.ie

b Department of Chemistry, Maynooth University, Ireland

c Department of Chemistry, University of Liege, Belgium

d Department of Chemical Science, University of Padua, Italy

e Department of Pharmaceutical and Pharmacological Science, University of Padua, Italy
E-mail: valentina.gandin@unipd.it

Abstract

A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.

Graphical abstract: A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

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Article information

DOI
https://doi.org/10.1039/C6CC08100B
Article type
Communication
Submitted
07 Oct 2016
Accepted
01 Dec 2016
First published
01 Dec 2016

Chem. Commun., 2017,53, 134-137

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A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

D. Montagner, B. Fresch, K. Browne, V. Gandin and A. Erxleben, Chem. Commun., 2017, 53, 134 DOI: 10.1039/C6CC08100B

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